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Influence of repeated painful procedures on prefrontal cortical pain responses in newborns.
MedLine Citation:
PMID:  20860706     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aim:  We examined whether previous experience of repeated skin punctures altered the correlation between prefrontal cortical pain responses and Premature Infant Pain Profile (PIPP) scores, compared with infants who had no experience of skin puncture. Methods:  Eighty infants at 37-42 weeks of gestational age were observed during clinically required blood sampling: full-term infants with no experience of painful skin-breaking procedures before data collection (controls; n = 30), full-term infants with the experience of painful skin-breaking procedures (n = 20) and preterm infants with the experience of painful skin-breaking procedures (n = 30). Results:  We found no significant differences in PIPP scores among groups. In controls, prefrontal activation in both hemispheres correlated with facial expression score of the PIPP (r = 0.53 for right prefrontal area; r = 0.37 for left prefrontal area) and the total score. In full-term infants with the experience of pain, there was no correlation between cortical activation and clinical pain scores. In preterm infants, prefrontal activation in both hemispheres correlated with the physiological component of the PIPP score (r = 0.36 for right prefrontal area; r = 0.41 for left prefrontal area). Conclusion:  Our findings may be useful in considering the effects of cumulative painfulexperience on emotion and stress in neonates.
Authors:
Mio Ozawa; Katsuya Kanda; Michio Hirata; Isao Kusakawa; Chieko Suzuki
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Publication Detail:
Type:  Journal Article     Date:  2010-10-08
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  100     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  198-203     Citation Subset:  IM    
Copyright Information:
© 2010 The Author(s)/Acta Paediatrica © 2010 Foundation Acta Paediatrica.
Affiliation:
.Department of Nursing Administration/Advanced Clinical Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan .Neonatal Intensive Care Unit, St. Luke's International Hospital, Tokyo, Japan .Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan.
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