| Influence of reinforcement schedule on ethanol consumption patterns in non-food restricted male C57BL/6J mice. | |
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MedLine Citation:
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PMID: 17452296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ethanol reinforcement should ideally be evaluated in animals that are not food deprived to ensure that the motivation behind its consumption is pharmacological, and not caloric, in nature. The objective of this work was to assess the influence of reinforcement schedule on ethanol intake in nondeprived mice. Male C57BL/6J mice were trained to respond on an ethanol-reinforced lever on a fixed ratio 4 reinforcement schedule for 10% ethanol (10E). The appetitive and consummatory phases were then procedurally separated by changing the response requirement (RR), so that mice were permitted 30-min continuous 10E access after completion of either four (RR4) or eight (RR8) responses. Phase separation yielded a heightened appetitive drive to acquire 10E access (as indexed by a significant decrease in the latency to first active lever and a trend toward a decrease in the latency to first sipper contact) and an augmented level of drinking (twofold elevation in the ethanol dose consumed). Robust extinction responding on the ethanol-appropriate lever indicated that ethanol was effective as a behavioral reinforcer. These results suggest that the separation of appetitive and consummatory phases of ethanol self-administration may prove useful in future evaluations of the pharmacological and genetic bases of ethanol reinforcement in mice. |
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Authors:
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Matthew M Ford; Andrea M Fretwell; Gregory P Mark; Deborah A Finn |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 41 ISSN: 0741-8329 ISO Abbreviation: Alcohol Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-04-24 Completed Date: 2007-06-14 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: United States |
Other Details:
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Languages: eng Pagination: 21-9 Citation Subset: IM |
Affiliation:
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Department of Behavioral Neuroscience, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239-3098, USA. fordma@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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psychology* Animals Appetitive Behavior Behavior, Animal* Central Nervous System Depressants / administration & dosage* Conditioning, Operant Consummatory Behavior Eating* Ethanol / administration & dosage* Extinction, Psychological Male Mice Mice, Inbred C57BL Models, Animal Motivation Reaction Time Reinforcement Schedule* Self Administration |
| Grant Support | |
ID/Acronym/Agency:
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AA015234/AA/NIAAA NIH HHS; AA07468/AA/NIAAA NIH HHS; AA10760/AA/NIAAA NIH HHS; AA12439/AA/NIAAA NIH HHS; AA13478/AA/NIAAA NIH HHS; DA07262/DA/NIDA NIH HHS; DA14639/DA/NIDA NIH HHS; F32 AA015234-01/AA/NIAAA NIH HHS; P60 AA010760-12/AA/NIAAA NIH HHS; R01 AA012439-06A2/AA/NIAAA NIH HHS; R01 DA014639-05/DA/NIDA NIH HHS; T32 AA007468-18/AA/NIAAA NIH HHS; T32 DA007262-15/DA/NIDA NIH HHS; U01 AA013478-05/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 64-17-5/Ethanol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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