Document Detail


Influence of reinforcement schedule on ethanol consumption patterns in non-food restricted male C57BL/6J mice.
MedLine Citation:
PMID:  17452296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethanol reinforcement should ideally be evaluated in animals that are not food deprived to ensure that the motivation behind its consumption is pharmacological, and not caloric, in nature. The objective of this work was to assess the influence of reinforcement schedule on ethanol intake in nondeprived mice. Male C57BL/6J mice were trained to respond on an ethanol-reinforced lever on a fixed ratio 4 reinforcement schedule for 10% ethanol (10E). The appetitive and consummatory phases were then procedurally separated by changing the response requirement (RR), so that mice were permitted 30-min continuous 10E access after completion of either four (RR4) or eight (RR8) responses. Phase separation yielded a heightened appetitive drive to acquire 10E access (as indexed by a significant decrease in the latency to first active lever and a trend toward a decrease in the latency to first sipper contact) and an augmented level of drinking (twofold elevation in the ethanol dose consumed). Robust extinction responding on the ethanol-appropriate lever indicated that ethanol was effective as a behavioral reinforcer. These results suggest that the separation of appetitive and consummatory phases of ethanol self-administration may prove useful in future evaluations of the pharmacological and genetic bases of ethanol reinforcement in mice.
Authors:
Matthew M Ford; Andrea M Fretwell; Gregory P Mark; Deborah A Finn
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  41     ISSN:  0741-8329     ISO Abbreviation:  Alcohol     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-06-14     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / psychology*
Animals
Appetitive Behavior
Behavior, Animal*
Central Nervous System Depressants / administration & dosage*
Conditioning, Operant
Consummatory Behavior
Eating*
Ethanol / administration & dosage*
Extinction, Psychological
Male
Mice
Mice, Inbred C57BL
Models, Animal
Motivation
Reaction Time
Reinforcement Schedule*
Self Administration
Grant Support
ID/Acronym/Agency:
AA015234/AA/NIAAA NIH HHS; AA07468/AA/NIAAA NIH HHS; AA10760/AA/NIAAA NIH HHS; AA12439/AA/NIAAA NIH HHS; AA13478/AA/NIAAA NIH HHS; DA07262/DA/NIDA NIH HHS; DA14639/DA/NIDA NIH HHS; F32 AA015234/AA/NIAAA NIH HHS; F32 AA015234-01/AA/NIAAA NIH HHS; P60 AA010760/AA/NIAAA NIH HHS; P60 AA010760-12/AA/NIAAA NIH HHS; R01 AA012439/AA/NIAAA NIH HHS; R01 AA012439-06A2/AA/NIAAA NIH HHS; R01 DA014639/DA/NIDA NIH HHS; R01 DA014639-05/DA/NIDA NIH HHS; T32 AA007468/AA/NIAAA NIH HHS; T32 AA007468-18/AA/NIAAA NIH HHS; T32 DA007262/DA/NIDA NIH HHS; T32 DA007262-15/DA/NIDA NIH HHS; U01 AA013478-05/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 3K9958V90M/Ethanol
Comments/Corrections

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