Document Detail


Influence of pulsatile perfusion upon renin release from the isolated perfused rat kidney.
MedLine Citation:
PMID:  2186359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well established that renin release from the juxtaglomerular epithelioid cells in the media of the afferent arteriole strongly depends on the mean renal perfusion pressure, whereas a possible influence of the pulsation of blood pressure on renin release has only occasionally been investigated, and the results are contradictory. Such an influence on renin release cannot be excluded because pulsation is known to modulate arterial baroreceptors and vascular tone in some resistance vessels. In the isolated perfused rat kidney, we found a pulsation amplitude-dependent inhibition of renin release that could be blocked either by vasodilatation or by calcium channel blockade. The inhibition occurred at perfusion pressures between 85 and 125 mm Hg. The underlying pulsation pressure-sensitive mechanism has to be ascribed integrating properties, because a constant-flow pressure rise to the "systolic" value of pulsatile perfusion resulted in virtually the same inhibition of renin release. Moreover, a reduced urine flow during pulsatile perfusion provides evidence for preglomerular constriction under these conditions. It is concluded that, besides pathological changes of renal perfusion pressure, variations of the pulse amplitudes, e.g. resulting from renal artery stenosis or atherosclerosis, may also influence renin release and contribute to renovascular hypertension.
Authors:
R Nobiling; K Münter; C P Bührle; E Hackenthal
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  415     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-06-13     Completed Date:  1990-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  713-7     Citation Subset:  IM    
Affiliation:
Physiologisches Institut, Universität Heidelberg, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diuresis
Kidney / metabolism*
Male
Perfusion
Pulsatile Flow
Rats
Rats, Inbred Strains
Renin / antagonists & inhibitors,  metabolism*
Time Factors
Chemical
Reg. No./Substance:
EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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