Document Detail

Influence of pulsatile perfusion upon renin release from the isolated perfused rat kidney.
MedLine Citation:
PMID:  2186359     Owner:  NLM     Status:  MEDLINE    
It is well established that renin release from the juxtaglomerular epithelioid cells in the media of the afferent arteriole strongly depends on the mean renal perfusion pressure, whereas a possible influence of the pulsation of blood pressure on renin release has only occasionally been investigated, and the results are contradictory. Such an influence on renin release cannot be excluded because pulsation is known to modulate arterial baroreceptors and vascular tone in some resistance vessels. In the isolated perfused rat kidney, we found a pulsation amplitude-dependent inhibition of renin release that could be blocked either by vasodilatation or by calcium channel blockade. The inhibition occurred at perfusion pressures between 85 and 125 mm Hg. The underlying pulsation pressure-sensitive mechanism has to be ascribed integrating properties, because a constant-flow pressure rise to the "systolic" value of pulsatile perfusion resulted in virtually the same inhibition of renin release. Moreover, a reduced urine flow during pulsatile perfusion provides evidence for preglomerular constriction under these conditions. It is concluded that, besides pathological changes of renal perfusion pressure, variations of the pulse amplitudes, e.g. resulting from renal artery stenosis or atherosclerosis, may also influence renin release and contribute to renovascular hypertension.
R Nobiling; K Münter; C P Bührle; E Hackenthal
Related Documents :
2850819 - Contribution of the renin-angiotensin system and of the sympathetic nervous system to b...
2409359 - Vasodilatation of small and large arteries in hypertension.
19010879 - Does the renin-angiotensin system participate in regulation of human vasculogenesis and...
8467569 - The angiotensin-converting enzyme inhibitor, perindopril, prevents cardiac hypertrophy ...
20613959 - Ppars in the renal regulation of systemic blood pressure.
2650709 - Extrarenal renin and blood pressure regulation. an alternative viewpoint.
18722549 - Cold acclimation induces physiological cardiac hypertrophy and increases assimilation o...
11506109 - Gel lubrication of the tracheal tube cuff reduces pulmonary aspiration.
9684469 - Humidity control tool for neonatal incubator.
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  415     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-06-13     Completed Date:  1990-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  713-7     Citation Subset:  IM    
Physiologisches Institut, Universität Heidelberg, Federal Republic of Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Kidney / metabolism*
Pulsatile Flow
Rats, Inbred Strains
Renin / antagonists & inhibitors,  metabolism*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evaluation of aztreonam and ampicillin vs. amikacin and ampicillin for treatment of neonatal bacteri...
Next Document:  DNA recombination during PCR.