Document Detail

Influence of proteinuria on renal Doppler sonographic measurements in chronic kidney disease and in diabetes mellitus.
MedLine Citation:
PMID:  21557251     Owner:  NLM     Status:  Publisher    
PURPOSE.: To evaluate the influence of proteinuria on renal Doppler sonographic (US) measurements in patients with chronic kidney disease (CKD) with or without diabetes mellitus (DM). METHODS.: Renal resistance index (RI), pulsatility index (PI), and maximum kidney length were measured by US in 113 patients suffering from CKD without DM (non-DM CKD patients) and in 120 patients with diabetic nephropathy (DM patients). Other data collected were sex, age, body mass index, blood pressure, estimated glomerular filtration rate, urinary protein level, and medical history. The effect of proteinuria on RI and PI was evaluated using single regression analyses, multiple regression analyses, and comparison of regression lines. RESULTS.: Single and multiple regression analyses revealed that RI and PI in the two subgroups and in the entire group of patients were correlated with urinary protein level (p < 0.05). Comparison of regression lines of each subgroup showed statistically significant differences in two regression intercepts concerning these indices in relation to urinary protein level (p < 0.001, RI: 0.71 in non-DM CKD patients versus 0.76 in DM patients, PI: 1.39 in non-DM CKD patients versus 1.60 in DM patients) (p < 0.001). CONCLUSIONS.: Renal RI and PI can reflect damages related to proteinuria and DM. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound 2011;
Aya Nakamori; Yutaka Ando; Hiroko Matsuda; Tomonori Kimura; Hironori Minami; Enyu Imai; Takafumi Yura
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-6
Journal Detail:
Title:  Journal of clinical ultrasound : JCU     Volume:  -     ISSN:  1097-0096     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401663     Medline TA:  J Clin Ultrasound     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Department of Pediatrics Nephrology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 777, Rochester, NY 14642; Department of Nephrology, Otemae Hospital, 1-5-34, Otemae, Chuo-ku, Osaka City, Osaka, Japan 540-0008; Department of Internal Medicine, Osaka Minami Medical Center, 2-1, Kidohigashi, Kawachinagano City, Osaka, Japan 586-8521.
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