Document Detail

Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients.
MedLine Citation:
PMID:  3588249     Owner:  NLM     Status:  MEDLINE    
A pharmacokinetic study after a single dose of ceftriaxone, cefoxitin, cefuroxime and ceftazidime was performed to investigate the influence of protein binding and severity of disease on the renal elimination. In intensive-care patients drug-protein binding was substantially less compared to that in volunteers and patients with less complicated diseases. This did not result in increased elimination but, due to increased apparent volumes of distribution, prolonged half-life times were observed. Consequently, in patients with complicated disease states a dosage regimen should be based on pharmacokinetic studies performed in a similar patient group.
R Van Dalen; T B Vree; I M Baars
Related Documents :
21170649 - Thymidylate synthase and thymidine phosphorylase as predictive markers of capecitabine ...
21342499 - Balanced massive transfusion ratios in multiple injury patients with traumatic brain in...
22245569 - Clinical study in chinese patients with late-infantile form neuronal ceroid lipofuscino...
21364139 - Functional variants of the hmga1 gene and type 2 diabetes mellitus.
21122499 - Clinical trial: preliminary efficacy and safety study of a new budesonide-mmx® 9 mg ex...
21401349 - Bmi, spkt/v, and sbp but not dbp are related to lvh in chinese maintenance hemodialysis...
24315829 - Landau-kleffner syndrome: a study of 29 patients.
8684389 - Response to botulinum toxin f in seronegative botulinum toxin a--resistant patients.
6637359 - The anatomical shape of the airway during endotracheal intubation.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmaceutisch weekblad. Scientific edition     Volume:  9     ISSN:  0167-6555     ISO Abbreviation:  Pharm Weekbl Sci     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-14     Completed Date:  1987-07-14     Revised Date:  2008-02-25    
Medline Journal Info:
Nlm Unique ID:  7907992     Medline TA:  Pharm Weekbl Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  98-103     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Cephalosporins / administration & dosage,  metabolism,  urine*
Chromatography, High Pressure Liquid
Critical Care
Middle Aged
Protein Binding
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of tick-borne fever on metabolism and renal clearance of sulfadimidine in goats.
Next Document:  D(-)3-hydroxybutyrate cotransport with Na in rat renal brush border membrane vesicles.