Document Detail


Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients.
MedLine Citation:
PMID:  3588249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A pharmacokinetic study after a single dose of ceftriaxone, cefoxitin, cefuroxime and ceftazidime was performed to investigate the influence of protein binding and severity of disease on the renal elimination. In intensive-care patients drug-protein binding was substantially less compared to that in volunteers and patients with less complicated diseases. This did not result in increased elimination but, due to increased apparent volumes of distribution, prolonged half-life times were observed. Consequently, in patients with complicated disease states a dosage regimen should be based on pharmacokinetic studies performed in a similar patient group.
Authors:
R Van Dalen; T B Vree; I M Baars
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmaceutisch weekblad. Scientific edition     Volume:  9     ISSN:  0167-6555     ISO Abbreviation:  Pharm Weekbl Sci     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-14     Completed Date:  1987-07-14     Revised Date:  2008-02-25    
Medline Journal Info:
Nlm Unique ID:  7907992     Medline TA:  Pharm Weekbl Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  98-103     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Cephalosporins / administration & dosage,  metabolism,  urine*
Chromatography, High Pressure Liquid
Critical Care
Humans
Kinetics
Middle Aged
Protein Binding
Chemical
Reg. No./Substance:
0/Cephalosporins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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