| Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients. | |
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MedLine Citation:
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PMID: 3588249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A pharmacokinetic study after a single dose of ceftriaxone, cefoxitin, cefuroxime and ceftazidime was performed to investigate the influence of protein binding and severity of disease on the renal elimination. In intensive-care patients drug-protein binding was substantially less compared to that in volunteers and patients with less complicated diseases. This did not result in increased elimination but, due to increased apparent volumes of distribution, prolonged half-life times were observed. Consequently, in patients with complicated disease states a dosage regimen should be based on pharmacokinetic studies performed in a similar patient group. |
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Authors:
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R Van Dalen; T B Vree; I M Baars |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmaceutisch weekblad. Scientific edition Volume: 9 ISSN: 0167-6555 ISO Abbreviation: Pharm Weekbl Sci Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-07-14 Completed Date: 1987-07-14 Revised Date: 2008-02-25 |
Medline Journal Info:
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Nlm Unique ID: 7907992 Medline TA: Pharm Weekbl Sci Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 98-103 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Cephalosporins / administration & dosage, metabolism, urine* Chromatography, High Pressure Liquid Critical Care Humans Kinetics Middle Aged Protein Binding |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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