Document Detail

Influence of the prostaglandin E1 analogue Rioprostil on the human gastric mucosa.
MedLine Citation:
PMID:  3111919     Owner:  NLM     Status:  MEDLINE    
Ten healthy volunteers received the prostaglandin E1 analogue Rioprostil 300 micrograms b.i.d. for 1 week. Endoscopically obtained biopsies were investigated with tritiated thymidine and autoradiography to determine the rate of cell proliferation and with a texture-analyzing system to measure the intracellular amount of mucus in the epithelial cells. Rioprostil did not alter the tritiated thymidine labeling index in the antral area but did significantly depress it in the fundic area. The mucus content was unchanged in the antrum but was significantly increased in the fundus. These observations indicate that Rioprostil given orally causes an enhanced cell maturation in the fundic area as well as an increased intracellular mucus content. Rioprostil seems to have no influence on the human antral area.
L B Svendsen; F Stener Jørgensen; O Hart Hansen; A Johansen; T Horn; J K Larsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestion     Volume:  37     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-17     Completed Date:  1987-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  29-34     Citation Subset:  IM    
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MeSH Terms
Anti-Ulcer Agents / pharmacology*
Cell Division / drug effects
Gastric Mucosa / drug effects*
Prostaglandins E / pharmacology*
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Prostaglandins E; 77287-05-9/Rioprostil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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