| Influence of prostacyclin on regional blood flow distribution in anesthetized dogs. | |
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MedLine Citation:
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PMID: 6762168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostacyclin (PGI2), a major metabolite of arachidonic acid, is widely distributed throughout the cardiovascular system and may influence vascular smooth muscle tone. To evaluate the effects of PGI2 on regional blood flow distribution in anesthetized dogs, the tracer microsphere reference sample method was used. Intravenous PGI2 infusions (0.5 and 1.0 microgram/kg/min) increased renal, adrenal, splenic, small intestinal, brain and pituitary blood flow, whereas pancreatic, fundic and skeletal muscle perfusion were diminished by PGI2. Hepatic and myocardial blood flow remained unchanged. This study demonstrates striking differences in regional vascular sensitivity to PGI2, which should be kept in mind when evaluating the potential therapeutic usefulness of PGI2 in a variety of clinical situations. |
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Authors:
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B A Schölkens; J Scholtholt; R Becker; W Jung; O Speth |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 260 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-04-07 Completed Date: 1983-04-07 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 244-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Dogs Epoprostenol / pharmacology* Female Heart / drug effects Hemodynamics / drug effects Male Microspheres Prostaglandins / pharmacology* Regional Blood Flow / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 35121-78-9/Epoprostenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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