Document Detail

Influence of (+)-propoxyphene on the hexachlorobenzene-induced porphyria of rats.
MedLine Citation:
PMID:  3879174     Owner:  NLM     Status:  MEDLINE    
The increased urinary porphyrin excretion after hexachlorobenzene (HCB) could be reduced by simultaneous application of (+)-4-(dimethylamino)-3-methyl-1,2-diphenyl-2-butanol propionate ((+)-propoxyphene) to female Wistar rats over a period of 60 days. Total porphyrin excretion and predominantly the higher carboxylated porphyrins, such as uroporphyrin were reduced under the influence of (+)-propoxyphene. (+)-Propoxyphene led to an increase of hepatic cytochrome P-450 content and the cytochrome P-450 dependent enzymes arylhydrocarbon-hydroxylase- and aminopyrine-N-demethylase activities, whereas the 7-ethoxycoumarine-deethylase activity was not changed. The simultaneous treatment of rats with HCB and (+)-propoxyphene decreased the HCB induced cytochrome P-450 content and the aminopyrine-N-demethylase activity. The arylhydrocarbon-hydroxylase activity, however, was increased, whereas no influence on the 7-ethoxycoumarine-deethylase activity could be demonstrated by (+)-propoxyphene treatment of HCB exposed rats. It is under discussion that a reduction of aminopyrine-N-demethylase activity by the drug in the liver alters the HCB metabolism resulting in a reduced production of a probable ultimative porphyrogenic agent.
H Merk; A von Zittwitz; K Bolsen; G Goerz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  35     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1985  
Date Detail:
Created Date:  1986-03-18     Completed Date:  1986-03-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1685-7     Citation Subset:  IM    
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MeSH Terms
7-Alkoxycoumarin O-Dealkylase
Aminopyrine N-Demethylase / metabolism
Aryl Hydrocarbon Hydroxylases / metabolism
Cytochrome P-450 Enzyme System / metabolism
Dextropropoxyphene / pharmacology*
Microsomes, Liver / enzymology
Mixed Function Oxygenases / metabolism
Oxygenases / metabolism
Porphyrias / chemically induced,  drug therapy*,  enzymology
Rats, Inbred Strains
Time Factors
Reg. No./Substance:
0/Chlorobenzenes; 118-74-1/Hexachlorobenzene; 469-62-5/Dextropropoxyphene; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.-/Mixed Function Oxygenases; EC 1.13.-/Oxygenases; EC 1.14.13.-/7-Alkoxycoumarin O-Dealkylase; EC Hydrocarbon Hydroxylases; EC 1.5.3.-/Aminopyrine N-Demethylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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