| Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults. | |
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MedLine Citation:
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PMID: 17761791 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the influence of insulin-like growth factor (IGF) pathway gene polymorphisms on muscle mass and strength responses to strength training (ST), we studied 128 White and Black men and women before and after a 10-wk single-leg knee extension ST program. One-repetition maximum strength, muscle volume (MV) via computed tomography, and muscle quality (MQ) were assessed at baseline and after 10 wk of ST. There was a significant combined IGF1 cytosine adenine (CA) repeat gene effect, which included both the IGF1 CA repeat main effect and IGF1 CA repeat x PPP3R1 insertion-deletion (I/D) gene x gene interaction effect, on the changes in strength (P < 0.01) and MQ (P < 0.05) with ST. There was a trend for a significant gene x gene interaction between IGF1 CA repeat and PPP3R1 I/D for changes in strength (P = 0.07) and MQ (P = 0.06) with ST. The influence of the PPP3R1 A-202C gene polymorphism on change in MV with ST approached significance (P = 0.06). The IGF1 CA repeat polymorphism had a significant influence on the change in strength and MV combined with ST (P < 0.05), whereas the influence of the PPP3R1 I/D polymorphism approached significance (P = 0.08). There were no associations between the IGFBP3 A-202C gene polymorphism and the muscle phenotypic responses to ST. These data suggest that two of the three IGF pathway gene polymorphisms identified in this study influence muscle phenotypic responses to ST in both black and white older men and women. |
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Authors:
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Brian D Hand; Matthew C Kostek; Robert E Ferrell; Matthew J Delmonico; Larry W Douglass; Stephen M Roth; James M Hagberg; Ben F Hurley |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2007-08-30 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 103 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-29 Completed Date: 2008-01-08 Revised Date: 2011-01-26 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1678-87 Citation Subset: IM |
Affiliation:
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Dept. of Kinesiology, Univ. of Maryland, College Park, MD 20742, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Americans
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genetics Age Factors Aged Aged, 80 and over Aging / genetics* Calcineurin Dinucleotide Repeats European Continental Ancestry Group / genetics Exercise / physiology* Female Gene Frequency Genotype Humans Insulin-Like Growth Factor Binding Proteins / genetics, metabolism Insulin-Like Growth Factor I / genetics*, metabolism Male Middle Aged Muscle Contraction* Muscle Strength Muscle, Skeletal / metabolism*, radiography Phenotype Phosphoprotein Phosphatases / genetics*, metabolism Polymorphism, Genetic* Promoter Regions, Genetic* Sex Factors Time Factors Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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AG-00268/AG/NIA NIH HHS; AG-021500/AG/NIA NIH HHS; AG-022791/AG/NIA NIH HHS; AG-1620501/AG/NIA NIH HHS; AG-4-2148/AG/NIA NIH HHS; K01 AG022791-05/AG/NIA NIH HHS; L30 AG024705-03/AG/NIA NIH HHS; R01 AG021500-01A1/AG/NIA NIH HHS; R01 AG021500-02/AG/NIA NIH HHS; R01 AG021500-03/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/IGFBP3 protein, human; 0/Insulin-Like Growth Factor Binding Proteins; 67763-96-6/Insulin-Like Growth Factor I; EC 3.1.3.16/Calcineurin; EC 3.1.3.16/PPP3R2 protein, human; EC 3.1.3.16/Phosphoprotein Phosphatases |
| Comments/Corrections | |
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