| Influence of prior exposure to low-dose adapting radiation on radiation-induced teratogenic effects in fetal mice with varying Trp53 function. | |
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MedLine Citation:
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PMID: 12236813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Teratogenesis in tails and limb digits of fetal mice with varying Trp53 status was examined after exposure of pregnant females to 4 Gy gamma radiation with and without a prior 30-cGy exposure. Prior low-dose exposure modified the teratogenic effects of radiation in a manner dependent upon Trp53 status and gestation time. A 4-Gy exposure on gestation day 11 resulted in tail shortening and digit abnormalities. A 30-cGy exposure 24 h prior to a 4-Gy radiation exposure on day 11 reduced the extent of both digit abnormalities and the tail-shortening effects in Trp53(+/+) fetuses and also reduced tail shortening in Trp53(+/-) fetuses, but to a lesser extent. However, the pre-exposure enhanced the tail-shortening effects of 4 Gy in Trp53(-/-) fetuses. In contrast, a 30-cGy exposure given 24 h prior to a 4-Gy exposure on gestation day 12 had no effect on the reduced tail length resulting from the 4-Gy exposure of Trp53(+/+) or Trp53(+/-) fetuses, but it partly protected Trp53(-/-) fetuses against reduced tail length. A 4-Gy exposure alone on day 12 did not result in any increase in the frequency of digit abnormalities in Trp53(-/-) fetuses so any protective effect of the preirradiation could not be detected. However, the preirradiation did result in protection against in digit abnormalities in Trp53(+/-) fetuses. We conclude that radiation-induced teratogenesis reflects both Trp53-dependent and independent processes that lead to apoptosis, and these respond differently to prior adapting doses. |
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Authors:
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R E J Mitchel; J-A Dolling; J Misonoh; D R Boreham |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiation research Volume: 158 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-18 Completed Date: 2002-10-18 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: United States |
Other Details:
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Languages: eng Pagination: 458-63 Citation Subset: IM; S |
Affiliation:
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Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Ontario, K0J 1J0 Canada. mitchelr@aecl.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Radiation-Induced
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etiology* Adaptation, Physiological Animals Female Fetal Death / etiology Limb Deformities, Congenital / etiology* Mice Mice, Inbred C57BL Tail / abnormalities* Tumor Suppressor Protein p53 / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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