Document Detail

Influence of prior exposure to low-dose adapting radiation on radiation-induced teratogenic effects in fetal mice with varying Trp53 function.
MedLine Citation:
PMID:  12236813     Owner:  NLM     Status:  MEDLINE    
Teratogenesis in tails and limb digits of fetal mice with varying Trp53 status was examined after exposure of pregnant females to 4 Gy gamma radiation with and without a prior 30-cGy exposure. Prior low-dose exposure modified the teratogenic effects of radiation in a manner dependent upon Trp53 status and gestation time. A 4-Gy exposure on gestation day 11 resulted in tail shortening and digit abnormalities. A 30-cGy exposure 24 h prior to a 4-Gy radiation exposure on day 11 reduced the extent of both digit abnormalities and the tail-shortening effects in Trp53(+/+) fetuses and also reduced tail shortening in Trp53(+/-) fetuses, but to a lesser extent. However, the pre-exposure enhanced the tail-shortening effects of 4 Gy in Trp53(-/-) fetuses. In contrast, a 30-cGy exposure given 24 h prior to a 4-Gy exposure on gestation day 12 had no effect on the reduced tail length resulting from the 4-Gy exposure of Trp53(+/+) or Trp53(+/-) fetuses, but it partly protected Trp53(-/-) fetuses against reduced tail length. A 4-Gy exposure alone on day 12 did not result in any increase in the frequency of digit abnormalities in Trp53(-/-) fetuses so any protective effect of the preirradiation could not be detected. However, the preirradiation did result in protection against in digit abnormalities in Trp53(+/-) fetuses. We conclude that radiation-induced teratogenesis reflects both Trp53-dependent and independent processes that lead to apoptosis, and these respond differently to prior adapting doses.
R E J Mitchel; J-A Dolling; J Misonoh; D R Boreham
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiation research     Volume:  158     ISSN:  0033-7587     ISO Abbreviation:  Radiat. Res.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-18     Completed Date:  2002-10-18     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0401245     Medline TA:  Radiat Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  458-63     Citation Subset:  IM; S    
Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Ontario, K0J 1J0 Canada.
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MeSH Terms
Abnormalities, Radiation-Induced / etiology*
Adaptation, Physiological
Fetal Death / etiology
Limb Deformities, Congenital / etiology*
Mice, Inbred C57BL
Tail / abnormalities*
Tumor Suppressor Protein p53 / physiology*
Reg. No./Substance:
0/Tumor Suppressor Protein p53

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