Document Detail


Influence of preventive therapy with quinapril on IL-6 level in patients with chronic stable angina.
MedLine Citation:
PMID:  17652834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We hypothesized that beneficial role of angiotensin converting enzyme inhibitors in stable coronary artery disease (CAD) therapy may involve (among others) their anti-inflammatory effects, which may be reflected by serum interleukin-6 (IL-6) levels. For that reason, we have investigated the influence of short-term administration of quinapril on serum IL-6 concentration. 124 patients suffering from stable CAD and matched for some of CAD risk factors were enrolled in our study. Patients were randomized to treatment with quinapril or control (placebo administration). Blood samples were taken twice: before and after four weeks of quinapril administration. The effect of quinapril administration was assessed under double-blind placebo-controlled conditions. We observed that quinapril reduced serum IL-6 concentration in almost all studied subgroups of patients (p < 0.001). Interestingly, such an effect was not observed in smokers. Additionally, we found that baseline IL-6 levels were higher in: smokers as compared with nonsmokers (p < 0.001), patients with total cholesterol (TC) to high density lipoprotein (HDL)-cholesterol ratio (TC/HDL-ch ratio) above 5 as compared with subjects with TC/HDL-ch < or = 5 (p = 0.001), and in patients who did not report any statin therapy in comparison with patients undergoing statin treatment (p = 0.023). In conclusion, quinapril may interfere with cytokine release by lowering IL-6 levels, which may be of particular importance for secondary prevention of stable CAD.
Authors:
Magdalena Gibas; Jolanta Miszczak-Smiałek; Edyta Madry; Jerzy Głuszek; Henryk Witmanowski; Janusz Piotrowski
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pharmacological reports : PR     Volume:  59     ISSN:  1734-1140     ISO Abbreviation:  Pharmacol Rep     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-07-26     Completed Date:  2008-01-17     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  101234999     Medline TA:  Pharmacol Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  330-8     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Medical Sciences, Swiecickiego 6, PL 60-781 Poznań, Poland. magda.gibas@hipokrates.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angina Pectoris / blood,  drug therapy*
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Aspirin / pharmacology
Cholesterol / blood
Cholesterol, HDL / blood
Chronic Disease
Female
Humans
Interleukin-6 / blood*
Male
Middle Aged
Tetrahydroisoquinolines / pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Cholesterol, HDL; 0/Interleukin-6; 0/Tetrahydroisoquinolines; 50-78-2/Aspirin; 57-88-5/Cholesterol; 82586-55-8/quinapril

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