Document Detail


Influence of prenatal cocaine exposure on full-term infant neurobehavioral functioning.
MedLine Citation:
PMID:  11792523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated infant neurobehavioral functioning during the newborn period in 334 full-term, African American neonates (187 cocaine exposed, 147 non-cocaine exposed) enrolled prospectively at birth, with documentation of drug exposure status through maternal interview and urine and meconium toxicology assays. Infants were assessed using the Brazelton Neonatal Behavioral Assessment Scale (BNBAS) during the newborn period (0-6 postnatal days). Findings from multivariate profile analyses support a consistent, modest effect of prenatal cocaine exposure on neurobehavioral functioning in full-term neonates. All of the BNBAS cluster scores, with the exception of abnormal reflexes, were similarly affected, sharing a common slope (D=-0.14; 95% CI=-0.27, -0.003; P=.046) representing a -0.14 point difference between cocaine-exposed and non-cocaine-exposed infants after controlling for prenatal exposure to alcohol, tobacco, and marijuana (ATM); maternal age, education, employment, primigravida status, and prenatal care visits; and infant sex and postnatal age in days. Fetal growth was also related to neurobehavioral functioning and, in part, mediated the relationship between cocaine exposure and the BNBAS cluster scores. Cocaine exposure during each trimester similarly influenced infant neurobehavioral profiles, with cocaine-associated deficits most pronounced in infants with exposure in all three trimesters. Results from qualitative and quantitative urine and meconium bioassay indicators further substantiated these results. Findings, while significant, represent modest effect sizes in full-term infants.
Authors:
C E Morrow; E S Bandstra; J C Anthony; A Y Ofir; L Xue; M L Reyes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  23     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2001 Nov-Dec
Date Detail:
Created Date:  2002-01-16     Completed Date:  2002-03-01     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  533-44     Citation Subset:  IM    
Affiliation:
Perinatal Chemical Addiction Research and Education (CARE) Program, Department of Pediatrics, University of Miami School of Medicine, PO Box 016960 (M-808), Miami, FL 33101, USA. cmorrow@med.miami.edu
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MeSH Terms
Descriptor/Qualifier:
African Americans
Birth Weight / drug effects
Cocaine-Related Disorders / urine*
Female
Florida
Humans
Infant Behavior / drug effects*
Infant, Newborn
Male
Meconium
Neurologic Examination
Pregnancy
Pregnancy Complications / urine*
Prenatal Exposure Delayed Effects*
Prospective Studies
Urban Population
Grant Support
ID/Acronym/Agency:
M01 RR 05280/RR/NCRR NIH HHS; R01 DA 06556/DA/NIDA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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