Document Detail


Influence of preload, afterload, and contractility on myocardial ultrasonic tissue characterization with integrated backscatter.
MedLine Citation:
PMID:  8783462     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Influence of hemodynamic changes in preload, afterload and contractility on myocardial integrated backscatter (IB) was studied in 26 adult mongrel dogs by measuring myocardial IB calibrated with the backscatter from the blood during volume infusion (preload alteration), during aortic constriction (afterload alteration), and during dobutamine or propranolol infusion (contractility alteration). Changes in preload, afterload or contractility did not significantly affect the calibrated myocardial IB either in the septum or in the posterior wall. Changes in preload and afterload did not affect the magnitude of cyclic variation in IB. However, dobutamine produced a significant increase in the magnitude of cyclic variation in IB and propranolol significantly decreased the magnitude of cyclic variation in IB. These data indicated that the calibrated myocardial IB is independent of preload, afterload and contractility, and that the magnitude of cyclic variation in IB is influenced by contractility. We may estimate static (related to histological changes such as fibrosis, edema, necrosis, and so on) and dynamic (related to myocardial contraction such as sarcomere length, muscle fiber orientation, and so on) properties of the myocardium more precisely using myocardial IB calibrated with the backscatter from the blood in addition to the magnitude of cyclic variation in IB.
Authors:
J Naito; T Masuyama; T Mano; K Yamamoto; Y Doi; H Kondo; R Nagano; M Inoue; M Hori
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  22     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  1996  
Date Detail:
Created Date:  1996-11-12     Completed Date:  1996-11-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  305-12     Citation Subset:  IM    
Affiliation:
First Department of Medicine, Osaka University School of Medicine, Suita, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / pharmacology
Adrenergic beta-Antagonists / pharmacology
Analysis of Variance
Animals
Coronary Circulation
Dobutamine / pharmacology
Dogs
Echocardiography / methods*
Heart / drug effects,  physiology*
Hemodilution*
Hemodynamics / drug effects
Myocardial Contraction / drug effects,  physiology*
Propranolol / pharmacology
Ventricular Function, Left / physiology
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 34368-04-2/Dobutamine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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