Document Detail

Influence of pregnancy on long-term progression of retinopathy in patients with type 1 diabetes.
MedLine Citation:
PMID:  18392803     Owner:  NLM     Status:  MEDLINE    
AIMS/HYPOTHESIS: Pregnancy in type 1 diabetic women is associated with risk of worsening of retinopathy. It has been reported that deterioration continues in the months after delivery, but direct data are lacking. It is also unclear what impact pregnancy has on the long-term progression of retinopathy. METHODS: We studied 59 women with type 1 diabetes who had retinal photographs before pregnancy and yearly for 5 years post pregnancy. These photographs were graded using the EURODIAB retinopathy grading system. RESULTS: The mean duration of diabetes was 14.4+/-8.2 years and mean age at pregnancy was 29.8+/-5.5 years. Mean HbA(1c) was 8.2+/-2.0% before pregnancy with tighter control during pregnancy itself. This value was high despite efforts to improve take-up of pre-conception care. Mean HbA(1c) was 8.6+/-1.5 during the follow-up period. At baseline, 43 (72.9%) women were free of retinopathy, 15 had non-proliferative retinopathy and one woman had previously had laser therapy. During pregnancy four women required laser therapy. Over the next 5 years none required laser therapy, although retinopathy worsened in 14 women. Ten-year follow-up data were available on 22 women, one of whom required laser therapy 8 years after pregnancy. Baseline retinopathy status was the only independent risk factor which predicted progression of retinopathy. CONCLUSIONS/INTERPRETATION: Pregnancy is not associated with post-partum worsening of retinopathy.
C S Arun; R Taylor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-08
Journal Detail:
Title:  Diabetologia     Volume:  51     ISSN:  0012-186X     ISO Abbreviation:  Diabetologia     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-01     Completed Date:  2008-08-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1041-5     Citation Subset:  IM    
Royal Victoria Infirmary and Diabetes Centre, Newcastle upon Tyne, UK.
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MeSH Terms
Diabetes Mellitus, Type 1 / blood,  complications*
Diabetic Retinopathy / blood,  complications*,  physiopathology*
Disease Progression
Follow-Up Studies
Hemoglobin A, Glycosylated / metabolism
Pregnancy Complications / blood*
Pregnancy Trimester, First
Pregnancy Trimester, Third
Time Factors
Reg. No./Substance:
0/Hemoglobin A, Glycosylated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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