Document Detail

Influence of pre-eclampsia on fetal growth.
MedLine Citation:
PMID:  12820837     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We examined the effect of pre-eclampsia on fetal growth in a cohort of pregnant women delivering singleton infants. METHODS: Analyses were restricted to 155 women with pre-eclampsia and 5570 normotensive women. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) after adjusting for confounders. We estimated ORs for very low birth weight (VLBW; < 1500 g), low birth weight (LBW; < 2500 g), and small for gestational age (SGA; weight < or = 10th centile by each gestational age, race, sex and parity strata) in relation to maternal pre-eclampsia status. RESULTS: After adjusting for maternal age, race, smoking, Medicaid status and gestational age, the OR for VLBW was 30.7 (95% CI 7.0-134.9). Pre-eclampsia was associated with a 3.8-fold increased risk of LBW (95% CI 1.9-7.5). Women with pre-eclampsia were 3.6 times more likely to deliver an SGA newborn as compared with normotensive women (95% CI 2.3-5.7). Advanced maternal age, African-American race, parity or smoking status did not modify the associations of pre-eclampsia with LBW and SGA. CONCLUSIONS: Our results are consistent with other reports that have documented a strong relationship between pre-eclampsia and restricted fetal growth. Further, our results expand the literature by documenting a particularly strong association between pre-eclampsia and VLBW. However, our findings regarding the relationship between pre-eclampsia and fetal growth may be confounded by unmeasured factors including maternal weight prior to pregnancy and pregnancy weight gain.
R Xiao; T K Sorensen; M A Williams; D A Luthy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  13     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-06-24     Completed Date:  2003-07-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-62     Citation Subset:  IM    
Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington 98122, USA.
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MeSH Terms
African Continental Ancestry Group / genetics
Birth Weight
Case-Control Studies
Cohort Studies
Fetal Growth Retardation / epidemiology*,  etiology*,  genetics
Fetal Macrosomia / epidemiology,  etiology
Infant, Newborn
Infant, Very Low Birth Weight
Maternal Age
Medical Records
Odds Ratio
Pre-Eclampsia / epidemiology*,  etiology*,  genetics
Pregnancy Outcome
Pregnancy, High-Risk
Regression Analysis
Retrospective Studies
Risk Factors
Sweden / epidemiology
Grant Support
R40 MC 00113//PHS HHS; R40 MC 00186//PHS HHS
Comment In:
J Matern Fetal Neonatal Med. 2003 Mar;13(3):145-6   [PMID:  12820834 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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