Document Detail

Influence of the postexercise acquisition delay on the detection of functional abnormalities in sestamibi-gated SPECT.
MedLine Citation:
PMID:  17556167     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Gated single photon emission computed tomography (SPECT) identifies functional changes produced by ischemia, but the influence of acquisition delay on their detection is not established. METHODS AND RESULTS: In 80 patients with known or suspected coronary artery disease, gated SPECT was acquired twice: first, less than 30 minutes after peak exercise (stress 1), and second, more than 45 minutes after peak exercise (stress 2). End-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF) were compared with perfusion. The relationship between the DeltaEF (stress EF - resting EF) and the summed difference score (SDS) was -0.443 (P < .0001) for stress 1 and -0.416 (P < .0001) for stress 2. In stress 1, EF increased in patients without inducible ischemia (SDS = 0) (57% +/- 10% vs 54% +/- 9% at rest, P < .02) and decreased in those with an SDS of 1 or greater (53% +/- 10.8% vs 55% +/- 9.6% at rest, P < .05). In stress 2, EF was unchanged in patients without ischemia (55.8% +/- 9.7%, P = .06) and decreased in the other patients (52.8% +/- 10.2%, P < .01). In patients without ischemia, both the EDV and ESV decreased significantly in stress 1 and were unchanged in stress 2. In patients with an SDS of 1 or greater, the EDV remained unchanged and the ESV minimally decreased in stress 1, whereas both volumes clearly and significantly increased in stress 2. CONCLUSIONS: The early acquisition of postexercise gated SPECT is slightly more effective in detecting ischemia-related functional changes; however, a delayed acquisition within 60 minutes still permits the detection of functional abnormalities in most patients.
Roberto Sciagrà; Barbara Sotgia; Manjola Dona; Alberto Pupi
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  14     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-06-08     Completed Date:  2007-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  334-40     Citation Subset:  IM    
Nuclear Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy.
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MeSH Terms
Aged, 80 and over
Coronary Artery Disease / radionuclide imaging*
Exercise Test / methods*
Gated Blood-Pool Imaging / methods
Image Enhancement / methods*
Middle Aged
Myocardial Ischemia / radionuclide imaging*
Radiopharmaceuticals / administration & dosage,  diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Technetium Tc 99m Sestamibi / administration & dosage,  diagnostic use*
Time Factors
Tomography, Emission-Computed, Single-Photon / methods*
Ventricular Dysfunction, Left / radionuclide imaging*
Reg. No./Substance:
0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi

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