Document Detail

Influence of portal pressure change on intestinal permeability in patients with portal hypertension.
MedLine Citation:
PMID:  14607676     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate intestinal permeability in patients with portal hypertension and its relationship with portal pressure. METHODS: Twenty patients with portal hypertension were divided into two groups (A, B), 10 patients per group. In group A, patients were treated with combined transjugular intrahepatic portosystemic shunt (TIPS) and modified Sugiura. In group B, patients were treated with modified Sugiura only. Intestinal permeability was assessed before operation, two weeks after TIPS, and two weeks after modified Sugiura; 20 healthy control subjects were also assessed. RESULTS: Intestinal permeability was significantly higher in the patients than in the control group (P<0.01). In group A, portal pressure, intestinal permeability decreased two weeks after TIPS (P<0.05), and no obvious change was noted two weeks after modified Sugiura; but they were significantly lower than those before TIPS (P<0.05). In group B, intestinal permeability was not different before and after operation. Intestinal permeability in group A was not different from that in group B before treatment, but significantly lower after modified Sugiura (P<0.05). Portal pressure was significantly correlated with intestinal permeability (r=0.627, P<0.01). CONCLUSIONS: This study shows that combined TIPS and modified Sugiura can lower portal pressure and intestinal permeability, and enhance the therapeutic efficacy on portal hypertension.
Wei-Hua Xu; Xing-Jiang Wu; Jie-Shou Li
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Hepatobiliary & pancreatic diseases international : HBPD INT     Volume:  1     ISSN:  1499-3872     ISO Abbreviation:  HBPD INT     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-11-10     Completed Date:  2004-05-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101151457     Medline TA:  Hepatobiliary Pancreat Dis Int     Country:  China    
Other Details:
Languages:  eng     Pagination:  510-4     Citation Subset:  IM    
Department of General Surgery, Jinling Hospital, Nanjing 210002, China.
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MeSH Terms
Blood Pressure*
Hypertension, Portal / physiopathology*,  surgery
Intestines / metabolism*
Middle Aged
Portal Vein / physiopathology*
Portasystemic Shunt, Transjugular Intrahepatic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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