Document Detail

Influence of portal blood on the development of systemic inflammation associated with experimental acute pancreatitis.
MedLine Citation:
PMID:  15674200     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The liver is a source of systemic proinflammatory mediators in acute pancreatitis. We have investigated the effects of blood from the pancreas and intestine in liver activation and lung inflammation during early stages of experimental acute pancreatitis in a rat model. METHODS: A portosystemic shunt and a mesosystemic shunt were created to prevent the passage of blood coming from the pancreas and the intestine, respectively, to the liver. Pancreatitis was induced by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct. After 3 hours, the inflammatory process in the lung and intestine, plasma levels of tumor necrosis factor (TNF)-alpha and their soluble receptor, and mRNA expression of inflammatory mediators in the lung were evaluated. RESULTS: Portocaval shunting of blood prevented the inflammatory process in the lung, an increase in plasma TNF-alpha concentration, and the expression of TNF-alpha, interleukin (IL)-1beta, and heat-shock protein (HSP)-72 in the lung, but had no effect on plasma levels of soluble TNF-alpha receptor or on expression of inducible nitric oxide synthase (iNOS) and macrophage inflammatory protein (MIP)-2 in the lung. In contrast, mesocaval shunting of blood did not modify any of the parameters evaluated. CONCLUSIONS: Pancreatic blood, but not intestinal blood, plays a key role in liver activation during experimental acute pancreatitis.
Sergio Hoyos; Susana Granell; Nicolas Heredia; Oriol Bulbena; Daniel Closa; Laureano Fernández-Cruz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgery     Volume:  137     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-27     Completed Date:  2005-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  186-91     Citation Subset:  AIM; IM    
Department of Surgery, Hospital Clinic, University of Barcelona, c/Rosselló 161, 7o 08036 Barcelona, Spain.
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MeSH Terms
Acute Disease
Base Sequence
Disease Models, Animal
Inflammation Mediators / metabolism
Intestines / blood supply
Liver / blood supply
Lung / immunology
Pancreas / blood supply
Pancreatitis / blood*,  etiology*,  genetics,  immunology
Portal System
Portasystemic Shunt, Surgical
RNA, Messenger / genetics,  metabolism
Rats, Sprague-Dawley
Receptors, Tumor Necrosis Factor, Type I / blood
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Inflammation Mediators; 0/RNA, Messenger; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Tumor Necrosis Factor-alpha

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