| Influence of polyunsaturated and saturated fats on plasma lipids and lipoproteins in man. | |
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MedLine Citation:
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PMID: 6424427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of varying polyunsaturated/saturated (P/S) fat ratios on the plasma levels of lipids, lipoproteins, and apolipoprotein A-I were assessed in six normal healthy subjects (three males, three females) with a particular focus on the P/S ratio which would offer optimal concentrations of both low-(LDL) and high-density lipoproteins (HDL). The isocaloric experimental diets contained 40% of calories as carbohydrate, 40% fat, and 20% protein; dietary cholesterol was 400 mg/day. The P/S ratio for the diets was 0.4, 1.0, or 2.0. Each diet was sequentially consumed for periods of 2 wk each. At the end of each 2-wk study period, plasma lipid, apolipoprotein A-I, and LDL and HDL cholesterol concentrations were determined; HDL were fractionated by zonal ultracentrifugation and lipid and protein composition determined. Compared to the P/S = 0.4 diet, mean plasma total cholesterol fell by approximately 6 and 12% on the P/S = 1.0 or P/S = 2.0 diets, respectively; plasma concentrations of LDL-cholesterol, HDL-cholesterol, and apolipoprotein A-I were also decreased on the polyunsaturated fat diets. The mean +/- SEM concentration (mg/dl) of HDL-cholesterol was 49.0 +/- 5.2 (P/S = 0.4), 44.0 +/- 3.8, (P/S = 1.0) and 41.0 +/- 3.7 (P/S = 2.0). As a result of a reduction in both LDL- and HDL-cholesterol on the polyunsaturate-rich diets, the ratios of HDL-cholesterol to plasma total cholesterol and HDL- to LDL-cholesterol were not significantly changed on the three diets.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R L Jackson; M L Kashyap; R L Barnhart; C Allen; E Hogg; C J Glueck |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 39 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-05-11 Completed Date: 1984-05-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 589-97 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoprotein A-I Apolipoproteins / blood Cholesterol / blood Dietary Fats / pharmacology* Fatty Acids, Unsaturated / pharmacology* Female Humans Lipids / blood* Lipoproteins / blood* Lipoproteins, HDL / blood Lipoproteins, LDL / blood Male |
| Grant Support | |
ID/Acronym/Agency:
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HL-22618/HL/NHLBI NIH HHS; HL-24744/HL/NHLBI NIH HHS; RR00068/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoproteins; 0/Dietary Fats; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 57-88-5/Cholesterol |
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