Document Detail

Influence of the pituitary on lipolysis and lipogenesis in fetal pig adipose tissue.
MedLine Citation:
PMID:  8381379     Owner:  NLM     Status:  MEDLINE    
This study was performed to verify and further characterize the role of neuroendocrine factors in the regulation of fetal adipose metabolism. On day 72 to 74 of gestation, pig fetuses in one uterine horn were hypophysectomized (hypoxed) by micro-cauterization, fetuses in the other horn served as sham controls. Fetuses were removed by laparotomy on day 110 of gestation. Slices of subcutaneous adipose tissue from control fetuses responded to lipolytic stimulation by norepinephrine alone (NE; 1 microgram/ml), NE plus adenosine deaminase (160 mUnits/ml) or dibutyryl cyclic AMP (5 mM). Adipose tissue from hypoxed fetuses, however, responded to lipolytic stimulation by only dibutyryl cyclic AMP, not NE. Lipogenesis in adipose tissue slices, as quantitated by 3H2O incorporation into triglyceride fatty acids, was increased 2.6 fold by hypophysectomy. These results demonstrate the necessity of a functioning pituitary in the normal regulation of fatty acid synthesis and receptor-mediated lipolytic response in developing fetal adipose tissue.
D B Hausman; G J Hausman; R J Martin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  25     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-08     Completed Date:  1993-03-08     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  IM    
University of Georgia, Athens.
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MeSH Terms
Adenosine Deaminase / pharmacology
Adipose Tissue / embryology*,  metabolism
Bucladesine / pharmacology
Fatty Acids / metabolism
Gestational Age
Lipids / biosynthesis*
Lipolysis* / drug effects
Norepinephrine / pharmacology
Pituitary Gland / embryology*,  physiology
Triglycerides / biosynthesis
Reg. No./Substance:
0/Fatty Acids; 0/Lipids; 0/Triglycerides; 10028-17-8/Tritium; 362-74-3/Bucladesine; 51-41-2/Norepinephrine; EC Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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