Document Detail


Influence of the pituitary on lipolysis and lipogenesis in fetal pig adipose tissue.
MedLine Citation:
PMID:  8381379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was performed to verify and further characterize the role of neuroendocrine factors in the regulation of fetal adipose metabolism. On day 72 to 74 of gestation, pig fetuses in one uterine horn were hypophysectomized (hypoxed) by micro-cauterization, fetuses in the other horn served as sham controls. Fetuses were removed by laparotomy on day 110 of gestation. Slices of subcutaneous adipose tissue from control fetuses responded to lipolytic stimulation by norepinephrine alone (NE; 1 microgram/ml), NE plus adenosine deaminase (160 mUnits/ml) or dibutyryl cyclic AMP (5 mM). Adipose tissue from hypoxed fetuses, however, responded to lipolytic stimulation by only dibutyryl cyclic AMP, not NE. Lipogenesis in adipose tissue slices, as quantitated by 3H2O incorporation into triglyceride fatty acids, was increased 2.6 fold by hypophysectomy. These results demonstrate the necessity of a functioning pituitary in the normal regulation of fatty acid synthesis and receptor-mediated lipolytic response in developing fetal adipose tissue.
Authors:
D B Hausman; G J Hausman; R J Martin
Related Documents :
5649639 - Adipose tissue and heat production in the new-born ox (bos taurus).
1138899 - Effect of methoxyindole 2-carboxylic acid and 4-pentenoic acid on adipose tissue metabo...
16460979 - Lipid content and fatty acid distribution in tissues from portuguese dogfish, leafscale...
2913289 - Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid synthesis and lipogenic enzymes...
3527759 - Placental transport and utilization of amino acids and carbohydrates.
1735609 - Fatty-acid composition of breast and iliac adipose tissue in breast-cancer patients.
6540979 - The relative effect of ascorbic acid on iron absorption from soy-based and milk-based i...
24129329 - Chiral suprastructures of asymmetric oligothiophene-hybrids induced by a single proline.
16657789 - Studies on the biosynthesis and metabolism of delta-aminolevulinic acid in chlorella.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  25     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-08     Completed Date:  1993-03-08     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  IM    
Affiliation:
University of Georgia, Athens.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine Deaminase / pharmacology
Adipose Tissue / embryology*,  metabolism
Animals
Bucladesine / pharmacology
Fatty Acids / metabolism
Gestational Age
Lipids / biosynthesis*
Lipolysis* / drug effects
Norepinephrine / pharmacology
Pituitary Gland / embryology*,  physiology
Swine
Triglycerides / biosynthesis
Tritium
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Lipids; 0/Triglycerides; 10028-17-8/Tritium; 362-74-3/Bucladesine; 51-41-2/Norepinephrine; EC 3.5.4.4/Adenosine Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Synaptosomal action of thyroid hormone: changes in Na(+)-K(+)-ATPase activity in adult rat cerebral ...
Next Document:  Patterns of antibodies to hepatitis C virus in patients with chronic non-A, non-B hepatitis and thei...