Document Detail

Influence of pirenzepine on colonic serotonin changes induced by short chain fatty acid.
MedLine Citation:
PMID:  7640399     Owner:  NLM     Status:  MEDLINE    
In this work we have demonstrated the influence of a short chain fatty acid (acetate) on the number of enterochromaffin (EC) cells containing serotonin (5HT), at two different pH (pH 6.9 absorptive stimuli, and pH 2.9 secretory stimuli), infused into the colon during one hour. The number of EC cells decrease significatively, specially in the cecum with a solution of low pH (2.9). The action of piprenzepine in preventing this reduction demonstrated that was partly mediated by a cholinergic receptor mechanism. On the other hand, a decrease on the release of 5HT to the lumen was a observed under the influence of pirenzepine. We conclude that the short chain fatty acid acetate, at a low pH induces the release of serotonin through a cholinergic mechanisms indicated by the inhibition observed with antimuscarinic drug.
D Celener; M I Ledesma de Paolo; E González; M Bonfanti; G Rosembeck; J C Bandi; O Tiscornia; L Bustos Fernández
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología     Volume:  44     ISSN:  0327-6309     ISO Abbreviation:  Acta Physiol Pharmacol Ther Latinoam     Publication Date:  1994  
Date Detail:
Created Date:  1995-09-15     Completed Date:  1995-09-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9200300     Medline TA:  Acta Physiol Pharmacol Ther Latinoam     Country:  ARGENTINA    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Intituto de Gastroenterología Dr. Jorge Pérez Companc, Buenos Aires, Argentina.
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MeSH Terms
Acetic Acid
Acetic Acids / pharmacology
Cecum / cytology,  drug effects,  secretion
Colon / cytology,  drug effects,  secretion*
Enterochromaffin Cells / drug effects,  secretion
Fatty Acids, Volatile / pharmacology*
Hydrogen-Ion Concentration
Infusions, Intravenous
Intestinal Mucosa / cytology
Pirenzepine / pharmacology*
Rats, Sprague-Dawley
Serotonin / secretion*
Reg. No./Substance:
0/Acetic Acids; 0/Fatty Acids, Volatile; 28797-61-7/Pirenzepine; 50-67-9/Serotonin; 64-19-7/Acetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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