Document Detail

Influence of physiologic cardiac hypertrophy on the prevalence of heart valve regurgitation.
MedLine Citation:
PMID:  18096734     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Chronic dynamic exercise leads to regulative and structural adaptations of the heart (athlete's heart). To what extent the enlargement and physiologic hypertrophy of the heart lead to changes in the function of the valves, particularly regurgitation, is not yet clear. The aim of this study was to examine the regurgitation levels of different states of "athlete's heart." METHODS: Our study population consisted of 5124 healthy subjects (4046 male and 1078 female, 18-60 years), regularly exercising 1 to 20 h/wk. Subjects were divided into 3 groups depending on their relative heart volumes (RHVs): (1) very enlarged heart group (VEHG; male, n = 1251; female, n = 201), with RHVs of greater than 14 (male) and 13 (female) mL/kg; (2) mildly enlarged heart group (MEHG; male, n = 702; female, n = 224), with RHVs of 12 to 14 (male) and 11 to 13 (female) mL/kg; and (3) control subjects (CS; male, n = 2093; female, n = 653), with RHVs of less than 12 (male) and 11 (female) mL/kg. RESULTS: According to US Food and Drug Administration criteria for valve regurgitation, it could be shown by Doppler sonography that as physiologic enlargement and hypertrophy increased significantly, the frequency and severity of aortic valve regurgitation (mean +/- SD: VEHG, 0.04 +/- 0.09; MEHG, 0.09 +/- 0.10; CS, 0.10 +/- 0.11; P < .05) and high mitral regurgitation (VEHG, 0.10 +/- 0.17; MEHG, 0.20 +/- 0.29; CS, 0.26 +/- 0.32; P < .01) decreased. On the contrary, pulmonary regurgitation (VEHG, 0.79 +/- 0.45; MEHG, 0.47 +/- 0.33; CS, 0.35 +/- 0.38; P < .01) and tricuspid valve regurgitation (VEHG, 0.42 +/- 0.29; MEHG, 0.47 +/- 0.33; CS, 0.35 +/- 0.38; P < .01) increased highly significantly with heart size. CONCLUSIONS: These findings strongly support the view of athlete's heart as a physiologic adaptation of the heart, at least on the left side, not causing increased valvular regurgitation.
Markus Sandrock; Arno Schmidt-Trucksäss; Daniel Schmitz; Andreas Niess; Hans-Hermann Dickhuth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  27     ISSN:  0278-4297     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-21     Completed Date:  2008-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-93     Citation Subset:  IM    
Department of Sports Medicine, Center for Internal Medicine, Tübingen University Hospital, Silcherstrasse 5, 72076, Tübingen, Germany.
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MeSH Terms
Cardiomegaly / complications*,  ultrasonography
Cross-Sectional Studies
Echocardiography, Doppler, Color*
Heart Valve Diseases / epidemiology,  etiology*,  ultrasonography
Middle Aged
Physical Fitness
Retrospective Studies
Statistics, Nonparametric

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