Document Detail

Influence of physical fitness and smoking on the coagulation system in hypertensive patients: effect on prothrombin fragment F1+2.
MedLine Citation:
PMID:  17603229     Owner:  NLM     Status:  MEDLINE    
OBJECT: Recently, prothrombin fragment F1+2 was shown to be a sensitive direct marker of thrombin formation. We examined the effect of lifestyle (including physical activity) on prothrombin fragment F1+2 levels. METHODS: Using the results of a questionnaire, the subjects were classified into groups on the basis of multiple medications, smoking, exercise, and drinking alcohol. The prothrombin fragment F1+2 levels were compared between each pair of groups and differences were analyzed using the unpaired t-test. Correlations between each parameter and the systolic and diastolic blood pressure, as well as with prothrombin fragment F1+2, were examined by multiple regression analysis. Patients The subjects were 109 patients who had essential hypertension without a past history of thrombotic events RESULTS: Smokers (1.47 +/- 0.75 vs 0.98 +/- 0.46 nmol/L, p<0.0001), and those without regular exercise (1.22 +/- 0.59 vs 0.68 +/- 0.30 nmol/L, p<0.0001) had higher levels of prothrombin fragment F1+2. Age, lack of exercise, and smoking were significant predictors of a high concentration of prothrombin fragment F1+2. Of the smokers, the patient with a regular exercise had low F1+2 compared with those without regular exercise (0.75 +/- 0.20 vs 2.01 +/- 0.49 nmol/L, p<0.0001. CONCLUSIONS: In patients with essential hypertension, age, smoking, and lack of regular exercise may increase the risk of thrombosis. Even in smokers, a regular exercise routine may reduce the tendency towards thrombus formation.
Junzo Nagashima; Haruki Musha; Hideomi Takada; Naoki Matsumoto; Rikiya Fujimaki; Narumi Ishige; Jiro Aono; Masahiro Murayama
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-07-02
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  46     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-02     Completed Date:  2007-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  933-6     Citation Subset:  IM    
Internal Medicine Section, Yokohama City Sports Medical Center, Yokohama.
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MeSH Terms
Biological Markers / analysis
Blood Coagulation / physiology
Cohort Studies
Disease Progression
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Hypertension / blood,  diagnosis*,  epidemiology
Life Style
Middle Aged
Peptide Fragments / blood*,  metabolism
Physical Fitness*
Predictive Value of Tests
Prothrombin / metabolism
Reference Values
Risk Assessment
Severity of Illness Index
Smoking / blood*,  epidemiology
Thrombosis / diagnosis*,  epidemiology,  prevention & control
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 78768-79-3/prothrombin fragment 2; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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