Document Detail


Influence of physical exercise on aging rats: II. Life-long exercise delays aging of tail tendon collagen.
MedLine Citation:
PMID:  8819097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Regular physical exercise has been shown to have a number of benefits compared with sedentary behaviour, such as delaying a number of aging changes and increasing the life expectancy but not the maximum lifespan. The purpose of this paper is to analyze the effects of physical exercise on the connective tissues of the body, especially systemic effects. We trained male Sprague-Dawley rats in a treadmill from the age of 5 months to 23 months. We analyzed the effects of training on tail tendons with respect to thermal stability of collagen and biomechanical properties of tendon bundles. Although tail tendons are attached to muscles, the are not weight-bearing as limb muscle tendons and can, therefore, be considered to be subjected mainly to systemic effects. The thermal stability of tail tendon collagen was significantly lower or "younger' for the trained group compared with the sedentary one. The biomechanical parameters were likewise "younger' with respect to maximum stress, although considerably stiffer compared with a 5-month-old base-line group. This suggests that there are several mechanisms, elicited by physical exercise, that act on the connective tissues. It can be concluded that life-long physical exercise has a beneficial influence on the connective tissues of the maturing and aging organism.
Authors:
A Viidik; H M Nielsen; M Skalicky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  88     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-10     Completed Date:  1996-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  139-48     Citation Subset:  IM    
Affiliation:
Institute of Anatomy, University of Aarhus, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism*
Analysis of Variance
Animals
Biomechanics
Collagen / metabolism*
Male
Physical Conditioning, Animal / physiology*
Rats
Rats, Sprague-Dawley
Tail
Temperature
Tendons / metabolism*
Time Factors
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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