Document Detail

Influence of phenytoin on isoproterenol-induced myocardial fibrosis in rats.
MedLine Citation:
PMID:  2301818     Owner:  NLM     Status:  MEDLINE    
A study was designed to determine whether phenytoin (PHE) prevents the myocardial necrosis and subsequent fibrosis produced by isoproterenol (ISO). Seven groups of female rats of the Wistar strain were used. Rats in groups 1 and 5 served as controls. Rats in group 3 were injected SC with 85 mg of ISO/kg of body weight for 2 consecutive days. Rats in groups 2 and 6 received 100 mg of PHE/kg orally. Rats in groups 4 and 7 received both PHE and ISO. There were 6 to 9 rats/group. Effects of ISO and PHE were evaluated gravimetrically, histologically, and electrocardiographically. Heart weight/body weight ratios for each group receiving ISO, with or without PHE, were greater than for groups not receiving ISO (P less than 0.05). Light microscopic examination of heart sections of rats given ISO alone or ISO + PHE revealed multiple and diffuse areas of fibrosis. Fibrosis in hearts from rats receiving PHE + ISO was less severe than that in hearts from rats receiving ISO alone, but the difference was not statistically significant. Electrocardiographic changes of statistical significance were not observed in rats receiving any compound (alone or in combination), when compared with the control groups of equal age.
F S Besbasi; R L Hamlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  51     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-26     Completed Date:  1990-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  36-9     Citation Subset:  IM    
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Ohio State University, Columbus 43210.
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MeSH Terms
Cardiomyopathies / chemically induced,  veterinary*
Fibrosis / chemically induced,  veterinary
Isoproterenol / antagonists & inhibitors*,  pharmacology
Myocardium / pathology*
Phenytoin / pharmacology*
Rats, Inbred Strains
Reg. No./Substance:
57-41-0/Phenytoin; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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