| Influence of phenoxymethylpenicillin on the vaginal ecosystem. | |
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MedLine Citation:
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PMID: 1563656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of phenoxymethylpenicillin on the bacterial flora of the vagina were investigated in 6 women who fulfilled the criteria of 'normality': predominance of lactobacilli, and absence of Enterobacteriaceae and fungi. Fourteen healthy women were enrolled and followed longitudinally; 8 of these were subsequently excluded because of divergence from normality. Following penicillin treatment, Gram-negative rods appeared in 4 of the remaining 6 women, and in 1 subject heavy growth of Candida albicans resulted. In 5 of the women there was no change in the lactobacillus count and a rise in pH was found in 4 subjects. In 1 woman, lactobacilli disappeared completely and were replaced by Escherichia coli. Concomitantly, high concentrations of endotoxins were found in the vaginal fluid. Treatment with penicillin may interfere with the normal vaginal bacterial flora and provide an environment favorable for Enterobacteriaceae and fungi. |
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Authors:
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I Sjöberg; E Grahn; S Håkansson; S E Holm |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 33 ISSN: 0378-7346 ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-05-19 Completed Date: 1992-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 42-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University Hospital, Umeå, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Candida albicans / drug effects*, growth & development, isolation & purification, pathogenicity Candidiasis, Vulvovaginal / etiology* Colony Count, Microbial Drug Resistance, Microbial Ecology Escherichia coli / drug effects*, growth & development, isolation & purification, pathogenicity Escherichia coli Infections / etiology* Female Humans Lactobacillus / drug effects*, growth & development, isolation & purification Penicillin V / administration & dosage, pharmacology* Time Factors Vagina / drug effects, microbiology* |
| Chemical | |
Reg. No./Substance:
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87-08-1/Penicillin V |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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