Document Detail


Influence of perfusate composition on drug disposition in the in-situ perfused rat lung.
MedLine Citation:
PMID:  19716867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compared the impact of two perfusates (A: 4.5% BSA-MOPS buffer and B: 4% dextran and 0.5% BSA-MOPS buffer) on the pharmacokinetics of the physiological markers [(3)H]-water, [(14)C]-sucrose, [(14)C]-antipyrine and Evans Blue-labelled albumin; and the drugs atenolol and propranolol using an in-situ single pass perfusion model in the rat lung. The multiple indicator dilution approach was used to define disposition. Similar perfusion pressures (17.6+/-6.71 vs 17.7+/-8.87 cm H(2)O), lung wet/dry ratio (6.14+/-1.16 vs 5.16+/-0.87), physiological spaces, and permeability-surface area products were found for the two perfusates. However, the recovery of propranolol using perfusate A (49.3+/-10.1%) was significantly higher than that using perfusate B (38.9+/-9.91%). This difference was consistent with changes in perfusate oncotic pressure associated with water and albumin distribution between the vascular, interstitial and cellular volumes of the lung.
Authors:
Xin Liu; Jimmy Yujia Wang; Alexander M Khlentzos; Frank Fontaine; Julijana Nikolovski; Lee-Ann Goh; Michael S Roberts
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-28
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  382     ISSN:  1873-3476     ISO Abbreviation:  Int J Pharm     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-27     Completed Date:  2010-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  192-7     Citation Subset:  IM    
Affiliation:
School of Medicine, Princess Alexandra Hospital, University of Queensland, Woollongabba, Queensland 4102, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antipyrine / pharmacokinetics
Atenolol / pharmacokinetics
Buffers
Carbon Radioisotopes
Deuterium Oxide / pharmacokinetics
Dextrans / metabolism,  pharmacology*
Evans Blue / pharmacokinetics
Hydrogen-Ion Concentration
Indicator Dilution Techniques*
Lung / blood supply,  drug effects*,  metabolism
Male
Models, Biological
Morpholines / metabolism,  pharmacology*
Perfusion / methods*
Permeability
Pressure
Propranolol / pharmacokinetics
Rats
Rats, Wistar
Serum Albumin, Bovine / metabolism,  pharmacology*
Sucrose / pharmacokinetics
Chemical
Reg. No./Substance:
0/Buffers; 0/Carbon Radioisotopes; 0/Morpholines; 0/Serum Albumin, Bovine; 1132-61-2/morpholinopropane sulfonic acid; 29122-68-7/Atenolol; 314-13-6/Evans Blue; 525-66-6/Propranolol; 57-50-1/Sucrose; 60-80-0/Antipyrine; 7789-20-0/Deuterium Oxide; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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