| Influence of perfusate composition on drug disposition in the in-situ perfused rat lung. | |
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MedLine Citation:
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PMID: 19716867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study compared the impact of two perfusates (A: 4.5% BSA-MOPS buffer and B: 4% dextran and 0.5% BSA-MOPS buffer) on the pharmacokinetics of the physiological markers [(3)H]-water, [(14)C]-sucrose, [(14)C]-antipyrine and Evans Blue-labelled albumin; and the drugs atenolol and propranolol using an in-situ single pass perfusion model in the rat lung. The multiple indicator dilution approach was used to define disposition. Similar perfusion pressures (17.6+/-6.71 vs 17.7+/-8.87 cm H(2)O), lung wet/dry ratio (6.14+/-1.16 vs 5.16+/-0.87), physiological spaces, and permeability-surface area products were found for the two perfusates. However, the recovery of propranolol using perfusate A (49.3+/-10.1%) was significantly higher than that using perfusate B (38.9+/-9.91%). This difference was consistent with changes in perfusate oncotic pressure associated with water and albumin distribution between the vascular, interstitial and cellular volumes of the lung. |
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Authors:
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Xin Liu; Jimmy Yujia Wang; Alexander M Khlentzos; Frank Fontaine; Julijana Nikolovski; Lee-Ann Goh; Michael S Roberts |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-28 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 382 ISSN: 1873-3476 ISO Abbreviation: Int J Pharm Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-10-27 Completed Date: 2010-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 192-7 Citation Subset: IM |
Affiliation:
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School of Medicine, Princess Alexandra Hospital, University of Queensland, Woollongabba, Queensland 4102, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antipyrine / pharmacokinetics Atenolol / pharmacokinetics Buffers Carbon Radioisotopes Deuterium Oxide / pharmacokinetics Dextrans / metabolism, pharmacology* Evans Blue / pharmacokinetics Hydrogen-Ion Concentration Indicator Dilution Techniques* Lung / blood supply, drug effects*, metabolism Male Models, Biological Morpholines / metabolism, pharmacology* Perfusion / methods* Permeability Pressure Propranolol / pharmacokinetics Rats Rats, Wistar Serum Albumin, Bovine / metabolism, pharmacology* Sucrose / pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Buffers; 0/Carbon Radioisotopes; 0/Morpholines; 0/Serum Albumin, Bovine; 1132-61-2/morpholinopropane sulfonic acid; 29122-68-7/Atenolol; 314-13-6/Evans Blue; 525-66-6/Propranolol; 57-50-1/Sucrose; 60-80-0/Antipyrine; 7789-20-0/Deuterium Oxide; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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