| Influence of perflubron emulsion particle size on blood half-life and febrile response in rats. | |
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MedLine Citation:
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PMID: 7849919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perfluorochemical (PFC) emulsions are particulate in nature and, as such, can cause delayed febrile reactions when injected intravenously. This study investigated the influence of emulsion particle size on intravascular retention and on body temperature changes in unrestrained conscious rats. Concentrated (60% to 90% w/v) emulsions based on perflubron (perfluorooctyl bromide [PFOB]) with mean particle sizes ranging from 0.05 microns to 0.63 microns were tested. Rats were fitted with a chronic jugular catheter and an abdominal body temperature telemetry unit. Fully recovered, conscious rats were monitored for 24 hours after infusion (dose = 2.7 g PFC/kg). Emulsion blood half-life (T1/2) was determined from blood perflubron levels measured by gas chromatography. Emulsions with a particle size of 0.2-0.3 microns caused fevers (6 to 8 hour duration) which peaked at 1-1.5 degrees C above normal (approximately 37.5 degrees C). Fevers could be blocked by i.v. treatment with either cyclooxygenase inhibitors (ibuprofen) or corticosteroids (dexamethasone). Both intensity and duration of the temperature response, quantified by area under the temperature curve, was decreased significantly for emulsions with a particle size < or = 0.12 micron. Blood T1/2 varied inversely with particle size, and was 3 to 4 fold longer for emulsions with a mean particle size < or = 0.2 micron. Thus, smaller emulsion particles more effectively evaded the reticuloendothelial system, which resulted in longer intravascular retention, less macrophage activity, and reduced febrile responses. |
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Authors:
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P E Keipert; S Otto; S F Flaim; J G Weers; E A Schutt; T J Pelura; D H Klein; T L Yaksh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Artificial cells, blood substitutes, and immobilization biotechnology Volume: 22 ISSN: 1073-1199 ISO Abbreviation: Artif Cells Blood Substit Immobil Biotechnol Publication Date: 1994 |
Date Detail:
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Created Date: 1995-03-16 Completed Date: 1995-03-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9431307 Medline TA: Artif Cells Blood Substit Immobil Biotechnol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1169-74 Citation Subset: IM |
Affiliation:
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Alliance Pharmaceutical Corp., San Diego, CA 92121. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Emulsions Fluorocarbons / adverse effects, blood, pharmacokinetics* Half-Life Male Particle Size Pyrogens / adverse effects, blood, pharmacokinetics* Rats Rats, Sprague-Dawley Telemetry / methods Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Emulsions; 0/Fluorocarbons; 0/Pyrogens; 423-55-2/perflubron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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