| Influence of the pattern of hypertrophy on left ventricular twist in hypertrophic cardiomyopathy. | |
| | |
MedLine Citation:
|
PMID: 18977803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/OBJECTIVE: Left ventricular (LV) twist has an important role in LV function. The influence of the pattern of LV hypertrophy on LV twist in hypertrophic cardiomyopathy (HCM) patients is unknown. This study sought to assess LV twist in a large group of HCM patients according to the pattern of LV hypertrophy. METHODS: The final study population consisted of 43 patients with HCM (mean age 43 (15) years, 31 men) and a typical sigmoidal (n = 16) or reverse septal curvature (n = 27) and 43 age-matched and gender-matched healthy control subjects. LV peak systolic rotation (Rot(max)), LV peak systolic twist (Twist(max)) and untwisting at 5%, 10% and 15% of diastole were determined by speckle tracking echocardiography (STE). RESULTS: Compared to control subjects, HCM patients had increased basal Rot(max) (-5.5 degrees (2.3 degrees ) vs -3.4 degrees (1.7 degrees ), p<0.001) and comparable apical Rot(max) (7.3 degrees (3.1 degrees ) vs 7.0 degrees (2.2 degrees ), p = NS), resulting in increased Twist(max) (12.4 degrees (4.0 degrees ) vs 9.9 degrees (2.7 degrees ), p<0.01). Untwisting at 5%, 10% and 15% of diastole was decreased in HCM patients (all p<0.05). There was a striking difference in apical Rot(max )(9.4 degrees (2.8 degrees ) vs 6.0 degrees (2.6 degrees ), p<0.01) and Twist(max) (15.3 degrees (3.2 degrees ) vs 10.6 degrees (3.3 degrees ), p<0.01) between HCM patients with a sigmoidal and reverse septal curvature. CONCLUSIONS: STE may provide novel non-invasive indices to assess LV function in patients with HCM. Apical Rot(max) and Twist(max) in HCM patients are dependent on the pattern of LV hypertrophy. |
| | |
Authors:
|
B M van Dalen; F Kauer; O I I Soliman; W B Vletter; M Michels; F J ten Cate; M L Geleijnse |
Related Documents
:
|
9420703 - Merits and limitations of radionuclide approaches to viability and future developments. 10616993 - Surgical repair of postinfarction structural failure of the posterobasal part of the he... 12759583 - Glomerular filtration rate estimation in patients with advanced chronic renal insuffici... |
Publication Detail:
|
Type: Journal Article Date: 2008-10-31 |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: 95 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-03-30 Completed Date: 2009-04-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
|
Languages: eng Pagination: 657-61 Citation Subset: AIM; IM |
Affiliation:
|
Department of Cardiology, The Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands. b.m.vandalen@erasmusmc.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cardiomyopathy, Hypertrophic / complications*, physiopathology Feasibility Studies Female Humans Hypertrophy, Left Ventricular / complications*, physiopathology Male Middle Aged Phenotype Rotation Systole Torsion Abnormality / etiology*, physiopathology, ultrasonography Ventricular Function, Left |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Local vessel injury following percutaneous coronary intervention does not promote early mobilisation...
Next Document: Cardiomyopathy, adult valve disease and heart failure in South America.