Document Detail


Influence of paternal immunity on idiotype expression of offspring.
MedLine Citation:
PMID:  3881340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The immune response of the rat to group A streptococcal carbohydrate (SACHO) and an associated idiotype, Id-1, was used to examine the effect of paternal immunity on Id-1 and SACHO-specific antibody expression by the offspring. First litters, conceived before immunization of the father, had significantly higher Id-1 levels than litters conceived by the same parental pairs after hyperimmunization of the father (P greater than 0.01). Total anti-SACHO levels were not affected. The effect appeared to be independent of the level of Id-1 expressed by the father or grandfather. No significant difference in Id-1 production was found between offspring of actively immune, neonatally Id-1 suppressed fathers and fathers expressing high levels of Id-1. We suggest that the paternal immunoregulatory influence acts via the maternal immune system to modify the idiotype repertoire expressed in the immune response of the offspring, and is not the result of genetic transmission of a trait acquired by the father. Some possible mechanisms of transmission are discussed.
Authors:
C A Cooper-Willis; J C Olson; M E Brewer; G A Leslie
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunogenetics     Volume:  21     ISSN:  0093-7711     ISO Abbreviation:  Immunogenetics     Publication Date:  1985  
Date Detail:
Created Date:  1985-03-08     Completed Date:  1985-03-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0420404     Medline TA:  Immunogenetics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Bacterial / genetics*
Antigens, Bacterial / immunology
Bacterial Vaccines / immunology
Female
Immune Tolerance
Immunization
Immunoglobulin Idiotypes / genetics*
Male
Maternal-Fetal Exchange
Paternity*
Polysaccharides, Bacterial / immunology
Pregnancy
Rats
Rats, Inbred F344 / immunology
Streptococcus pyogenes / immunology
Grant Support
ID/Acronym/Agency:
HD 12381/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Bacterial Vaccines; 0/Immunoglobulin Idiotypes; 0/Polysaccharides, Bacterial; 0/streptococcal group A cell wall carbohydrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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