| Influence of paternal immunity on idiotype expression of offspring. | |
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MedLine Citation:
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PMID: 3881340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immune response of the rat to group A streptococcal carbohydrate (SACHO) and an associated idiotype, Id-1, was used to examine the effect of paternal immunity on Id-1 and SACHO-specific antibody expression by the offspring. First litters, conceived before immunization of the father, had significantly higher Id-1 levels than litters conceived by the same parental pairs after hyperimmunization of the father (P greater than 0.01). Total anti-SACHO levels were not affected. The effect appeared to be independent of the level of Id-1 expressed by the father or grandfather. No significant difference in Id-1 production was found between offspring of actively immune, neonatally Id-1 suppressed fathers and fathers expressing high levels of Id-1. We suggest that the paternal immunoregulatory influence acts via the maternal immune system to modify the idiotype repertoire expressed in the immune response of the offspring, and is not the result of genetic transmission of a trait acquired by the father. Some possible mechanisms of transmission are discussed. |
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Authors:
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C A Cooper-Willis; J C Olson; M E Brewer; G A Leslie |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Immunogenetics Volume: 21 ISSN: 0093-7711 ISO Abbreviation: Immunogenetics Publication Date: 1985 |
Date Detail:
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Created Date: 1985-03-08 Completed Date: 1985-03-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0420404 Medline TA: Immunogenetics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-10 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Bacterial / genetics* Antigens, Bacterial / immunology Bacterial Vaccines / immunology Female Immune Tolerance Immunization Immunoglobulin Idiotypes / genetics* Male Maternal-Fetal Exchange Paternity* Polysaccharides, Bacterial / immunology Pregnancy Rats Rats, Inbred F344 / immunology Streptococcus pyogenes / immunology |
| Grant Support | |
ID/Acronym/Agency:
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HD 12381/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Bacterial Vaccines; 0/Immunoglobulin Idiotypes; 0/Polysaccharides, Bacterial; 0/streptococcal group A cell wall carbohydrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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