| Influence of ovariectomy on cardiac oxidative stress in a renovascular hypertension model. | |
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MedLine Citation:
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PMID: 22900708 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the potential influence of endogenous ovarian hormones on cardiac oxidative stress in renovascular hypertension. Female Wistar rats (N = 10 per group) were divided among 4 groups: (i) normotensive control; (ii) hypertensive control; (iii) normotensive ovariectomized; and (iv) hypertensive ovariectomized rats. To induce hypertension, 2-kidney 1-clip (2K1C) Goldblatt's method was followed. Blood pressure (BP) was enhanced (25%) in 2K1C and it was not further altered in hypertensive ovariectomized animals. Lipid peroxidation (measured by thiobarbituric acid reactive substances; TBARS) increased in heart homogenates after ovariectomy (253%) and was additionally augmented when associated with hypertension (by 28%). Superoxide dismutase and catalase activities were similar in both hypertensive groups. Hypertension enhanced glutathione peroxidase activity (75%), but the association with ovariectomy prevented this change. Total radical trapping antioxidant potential (TRAP) decreased in hypertensive rats (34%) and was recovered when associated with ovariectomy. However, this adaptation seems not to be sufficient to avoid the increased oxidative damage in ovariectomized hypertensive animals. These results suggest a protective role for physiological ovarian hormones in the cardiac oxidative stress induced by 2K1C hypertension. |
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Authors:
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Jaqueline Barp; Carmem Luiza Sartório; Cristina Campos; Susana Francisca Llesuy; Alex Sander Araujo; Adriane Belló-Klein |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-17 |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: - ISSN: 1205-7541 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Cardiovascular Physiology Laboratory, Federal University of Rio Grande do Sul (UFRGS), Avenida Sarmento Leite 500, CEP 90050170, Porto Alegre, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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