Document Detail


Influence of osteoarthritis on serum marker levels of bone formation and resorption in patients with benign prostatic hypertrophy.
MedLine Citation:
PMID:  9477188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of this study was to investigate the influence of osteoarthritis of lumbar vertebrae on serum bone formation and resorption marker levels of patients with benign prostatic hypertrophy (BPH). METHODS: Serum levels of carboxyterminal propeptide of type I procollagen (PICP), alkaline phosphatase (ALP), carboxyterminal telopeptide of type I collagen (ICTP), and prostate-specific antigen (PSA) were examined in 40 patients with BPH, and the presence of osteoarthritis at the lumbar vertebrae of the patients was evaluated by plain x-ray-p. RESULTS: Findings of osteoarthritis were observed in 23 of the 40 patients (58%), and 10 of the patients had severe osteoarthritis (involving at least 2 lumbar vertebral bodies). The serum levels of PICP, ALP, ICTP, and PSA of the patients without osteoarthritis findings were not different from those of the patients with osteoarthritis or severe osteoarthritis. CONCLUSION: The influence of osteoarthritis on serum bone formation and resorption marker levels of patients with BPH appears to be rather slight, if there is any influence at all.
Authors:
S Akimoto; Y Furuya; K Akakura; J Shimazaki; H Ito
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  4     ISSN:  0919-8172     ISO Abbreviation:  Int. J. Urol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-04-08     Completed Date:  1998-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  580-2     Citation Subset:  IM    
Affiliation:
Department of Urology, School of Medicine, Chiba University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alkaline Phosphatase / blood
Biological Markers / blood*
Bone Development*
Bone Resorption / blood*,  radiography
Collagen / blood
Collagen Type I
Humans
Lumbar Vertebrae*
Male
Middle Aged
Peptide Fragments / blood
Peptides / blood
Procollagen / blood
Prostate-Specific Antigen / blood
Prostatic Hyperplasia / blood*,  complications
Radioimmunoassay
Retrospective Studies
Spinal Osteophytosis / blood*,  radiography
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/Peptide Fragments; 0/Peptides; 0/Procollagen; 0/collagen type I trimeric cross-linked peptide; 0/procollagen type I carboxy terminal peptide; 9007-34-5/Collagen; EC 3.1.3.1/Alkaline Phosphatase; EC 3.4.21.77/Prostate-Specific Antigen

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