Document Detail

Influence of osmolality, short chain fatty acids and deoxycholic acid on mucus secretion in the rat colon.
MedLine Citation:
PMID:  7155804     Owner:  NLM     Status:  MEDLINE    
Mucus secretion into the rat colon has been measured in situ using a single perfusion technique. Protein, sialic acid and hexose concentrations in the perfusion solution were found to give reliable estimates of mucus output if samples were homogenized prior to analysis. Mucus output as indicated by an increase in the concentration of mucus constituents was higher when the solution was hypotonic (270 mosm . kg-1) or hypertonic (370 mosm . kg-1) than when isotonic solutions (320 mosm . kg-1) were used. The proportion of hexoses and sialic acid to protein was 23 and 14% at low, 23 and 11% at high osmolality, and 21 and 13% when isotonic solutions were used. Deoxycholic acid (DCA, 4 mmol . 1(-1)) increased the net secretion of mucus constituents 3 fold, whereas short chain fatty acids (SCFA) had no effect. Mucus composition during all treatments did not change significantly, even when stimulated with DCA. When mucus was released from the epithelial surface by previous perfusion with a DCA containing solution, net water and SCFA absorption rates and mucus output were significantly lowered for 2 to 3 h. However, no correlation between mucus secretion and SCFA absorption was found, indicating that a role for mucus as a diffusion barrier to SCFA is unlikely. Mucus output, which indicates the amount of mucus released from the epithelial surface, probably depends on the direction of net water movement, which follows the osmotic gradient between colon lumen and blood.
K Rübsamen; H Hörnicke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  395     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-03-17     Completed Date:  1983-03-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  306-11     Citation Subset:  IM    
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MeSH Terms
Colon / secretion*
Deoxycholic Acid / pharmacology*
Fatty Acids / pharmacology*
Mucus / secretion*
Osmolar Concentration*
Rats / physiology*
Rats, Inbred Strains
Water / metabolism
Reg. No./Substance:
0/Fatty Acids; 7732-18-5/Water; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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