Document Detail

Influence of oral vitamin E therapy on micro-inflammation and cardiovascular disease markers in chronic hemodialysis patients.
MedLine Citation:
PMID:  16825088     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to evaluate the influence of oral vitamin E therapy on serum concentrations of several markers of micro-inflammation and cardiovascular disease in chronic hemodialysis (HD) patients. METHODS: 29 HD patients were randomized into two groups: 15 patients were treated orally with 400 mg of vitamin E daily for a period of five weeks, and 14 patients received no antioxidant supplementation. Before and after vitamin E therapy, serum concentrations of vitamin E (high-performance liquid chromatography), pregnancy-associated plasma protein-A (immunochemical--TRACE assay), C-reactive protein (nephelometry), intercellular adhesion molecule-1 (ELISA), and E-selectin (ELISA) were measured. HD patients were compared with 16 healthy controls. RESULTS: Baseline serum concentrations of PAPP-A and CRP were significantly higher in HD patients than in healthy controls (PAPP-A: 26.23+/-11.94 vs. 11.41+/-1.94 mIU/L, p<0.001; CRP: 5.20+/-3.50 vs. 3.40+/-3.80 mg/L, p<0.05). After five weeks of oral vitamin E intake, serum PAPP-A, CRP, ICAM-1, and E-selectin concentrations remained unchanged in both groups of HD patients. CONCLUSION: Chronic micro-inflammation in HD patients is documented by the elevation of CRP and PAPP-A. A daily oral dose of 400 mg of vitamin E does not seem to be able to reduce enhanced oxidative stress and micro-inflammation in chronic HD patients.
Magdalena Hodkova; Sylvie Dusilova-Sulkova; Marta Kalousova; Jirina Soukupova; Tomas Zima; Dana Mikova; Ivan Matous Malbohan; Jirina Bartunkova
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Renal failure     Volume:  28     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-07     Completed Date:  2006-08-29     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-9     Citation Subset:  IM    
Department of Nephrology, Institute of Clinical Chemistry and Laboratory Diagnostics, General Teaching Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic.
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MeSH Terms
Administration, Oral
Biological Markers / blood*
C-Reactive Protein / analysis*
Cardiovascular Diseases / blood*,  etiology
E-Selectin / blood*
Inflammation / blood
Intercellular Adhesion Molecule-1 / blood*
Kidney Failure, Chronic / complications,  therapy
Middle Aged
Pregnancy-Associated Plasma Protein-A / analysis*
Renal Dialysis*
Vitamin E / administration & dosage*,  blood
Reg. No./Substance:
0/Biological Markers; 0/E-Selectin; 126547-89-5/Intercellular Adhesion Molecule-1; 1406-18-4/Vitamin E; 9007-41-4/C-Reactive Protein; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A
Comment In:
Ren Fail. 2007;29(2):245-6   [PMID:  17365946 ]

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