Document Detail

Influence of ondansetron on gastric sensorimotor responses to short duodenal acid infusion in healthy volunteers.
MedLine Citation:
PMID:  21114584     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Duodenal acid infusion induces gastric relaxation and sensitization to distension in healthy volunteers. The acid-sensitive mechanism is still unknown. We hypothesized that 5HT(3)-blockade can inhibit the acid-induced duodenogastric sensorimotor reflex in healthy volunteers.
METHODS: Fourteen healthy volunteers were included in a randomized, double-blind placebo-controlled cross-over trial. An infusion tube with attached pH-electrode was positioned in the duodenum and a barostat balloon was located in the gastric fundus. Proximal gastric volume and sensitivity to distension were assessed before and during duodenal acid infusion and after pretreatment with intravenous (i.v.) ondansetron (a 5HT(3)-receptor antagonist, 8 mg) or saline. An overall perception score (0-6) and an assessment of nine dyspeptic symptoms by visual analogue scales (VAS) were obtained. Results are given as mean ± SEM.
KEY RESULTS: Ondansetron had no effect on duodenal pH and on the acid-induced increase of proximal gastric volume (increase of 80 ± 20 vs 83 ± 15 mL after ondansetron and placebo; effect of acid <0.001, between treatments ns). After ondansetron, the overall perception score during duodenal acidification and gastric distension was significantly decreased compared with placebo (P=0.01). There was no effect of ondansetron on the individual dyspeptic symptoms.
CONCLUSIONS & INFERENCES: Ondansetron decreased gastric sensitivity during duodenal acid infusion and gastric distension. 5HT(3)-receptors are involved in acid-induced duodenogastric sensitization, but not in the duodenogastric inhibitory motor reflex.
T Vanuytsel; G Karamanolis; L Van Oudenhove; L V Oudenhove; R Vos; J Tack
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-11-28
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  23     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-09     Completed Date:  2011-05-31     Revised Date:  2012-01-31    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  226-32, e115     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Center for Gastroenterological Research, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium.
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MeSH Terms
Acids / pharmacology*
Cross-Over Studies
Double-Blind Method
Duodenum / drug effects*,  physiology
Hydrogen-Ion Concentration
Manometry / instrumentation,  methods
Muscle Tonus / drug effects
Ondansetron / pharmacology*
Serotonin 5-HT3 Receptor Antagonists / pharmacology
Serotonin Antagonists / pharmacology
Stomach / drug effects*,  physiology*
Young Adult
Reg. No./Substance:
0/Acids; 0/Placebos; 0/Serotonin 5-HT3 Receptor Antagonists; 0/Serotonin Antagonists; 99614-02-5/Ondansetron
Erratum In:
Neurogastroenterol Motil. 2012 Jan;24(1):94
Note: Oudenhove, L V [corrected to Van Oudenhove, L]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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