Document Detail

Influence of omega-3 fatty acids from the flaxseed (Linum usitatissimum) on the brain development of newborn rats.
MedLine Citation:
PMID:  22072343     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The importance of essential fatty acids, in particular the omega-3 family, in the central nervous system development of newborns is well documented. The flaxseed (Linum usitatissimum) is considered one of the best vegetable sources of omega-3 fatty acids. The influence of omega-3 fatty acids from flaxseed on the brain development of newborn rats was evaluated.
MATERIAL AND METHODS: Pups of the F1 generation were obtained from 18 female Wistar rats divided in 3 groups (n=6), FG: fed with diet based on Flaxseed added with casein, CG: Casein, and MCG: Modified Casein supplemented with fibers and soybean oil. Newborn pups were weighted and submitted to euthanasia; brains were collected for evaluation of weight and lipid profile through gaseous chromatography.
RESULTS: Significant increase in brain weight (39%) and relative brain weight (37%) was verified in pups from mothers fed with flaxseed diet. The omega-3 (n-3) fatty acids from the flaxseed were found in abundance in the diet made with this oleaginous and also significant increase in docosahexaenoic acid (DHA) (38%), as well as in total of omega-3 (n-3) fatty acids (62%).
CONCLUSION: Maternal diet of flaxseed during pregnancy influences the incorporation of omega-3 fatty acid in the composition of brain tissue, assuring a good development of this organ in newborn rats.
K C Lenzi Almeida; G Teles Boaventura; M A Guzmán Silva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrición hospitalaria     Volume:  26     ISSN:  1699-5198     ISO Abbreviation:  Nutr Hosp     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-11-10     Completed Date:  2012-03-12     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9100365     Medline TA:  Nutr Hosp     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  991-6     Citation Subset:  IM    
Universidade Federal Fluminense (UFF), Department of Nutrition and Dietary, RJ, Brazil.
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MeSH Terms
Animals, Newborn
Body Weight / drug effects
Brain / drug effects,  growth & development*
Brain Chemistry / drug effects
Fatty Acids / analysis
Fatty Acids, Omega-3 / pharmacology*
Flax / chemistry*
Lipid Metabolism / drug effects
Organ Size / drug effects
Seeds / chemistry
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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