| Influence of omega-3 fatty acids from the flaxseed (Linum usitatissimum) on the brain development of newborn rats. | |
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MedLine Citation:
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PMID: 22072343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The importance of essential fatty acids, in particular the omega-3 family, in the central nervous system development of newborns is well documented. The flaxseed (Linum usitatissimum) is considered one of the best vegetable sources of omega-3 fatty acids. The influence of omega-3 fatty acids from flaxseed on the brain development of newborn rats was evaluated. MATERIAL AND METHODS: Pups of the F1 generation were obtained from 18 female Wistar rats divided in 3 groups (n=6), FG: fed with diet based on Flaxseed added with casein, CG: Casein, and MCG: Modified Casein supplemented with fibers and soybean oil. Newborn pups were weighted and submitted to euthanasia; brains were collected for evaluation of weight and lipid profile through gaseous chromatography. RESULTS: Significant increase in brain weight (39%) and relative brain weight (37%) was verified in pups from mothers fed with flaxseed diet. The omega-3 (n-3) fatty acids from the flaxseed were found in abundance in the diet made with this oleaginous and also significant increase in docosahexaenoic acid (DHA) (38%), as well as in total of omega-3 (n-3) fatty acids (62%). CONCLUSION: Maternal diet of flaxseed during pregnancy influences the incorporation of omega-3 fatty acid in the composition of brain tissue, assuring a good development of this organ in newborn rats. |
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Authors:
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K C Lenzi Almeida; G Teles Boaventura; M A Guzmán Silva |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Volume: 26 ISSN: 1699-5198 ISO Abbreviation: Nutr Hosp Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-11-10 Completed Date: 2012-03-12 Revised Date: 2012-05-09 |
Medline Journal Info:
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Nlm Unique ID: 9100365 Medline TA: Nutr Hosp Country: Spain |
Other Details:
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Languages: eng Pagination: 991-6 Citation Subset: IM |
Affiliation:
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Universidade Federal Fluminense (UFF), Department of Nutrition and Dietary, RJ, Brazil. calvilenzi@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Body Weight / drug effects Brain / drug effects, growth & development* Brain Chemistry / drug effects Diet Fatty Acids / analysis Fatty Acids, Omega-3 / pharmacology* Female Flax / chemistry* Lipid Metabolism / drug effects Male Organ Size / drug effects Rats Seeds / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Omega-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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