Document Detail

Influence of omega-3 and omega-6 fatty acid sources on prostaglandin levels in mice.
MedLine Citation:
PMID:  2770427     Owner:  NLM     Status:  MEDLINE    
Studies from this laboratory, employing a hairless mouse model, have indicated that a polyunsaturated fatty acid source rich in omega-3 (n-3) fatty acid (FA) inhibits ultraviolet (UV)-carcinogenic expression, when compared to that of diets containing predominantly n-6 fatty acids. Omega-3 FA is a poor substrate for cyclooxygenase, the rate-limiting step in prostaglandin (PG) synthesis--the latter, particularly PGE2, are known to influence tumor biology. Based upon this rationale, plasma and cutaneous PGE2 levels were determined from hairless mice fed diets containing either 4% or 12% corn or menhaden oil. After two weeks on the respective diets, plasma PGE2 levels of corn oil-fed animals were approximately 6-fold greater than those of the menhaden oil-fed groups. A similar response was found in the dermis. Although the relationship to carcinogenic expression is unknown, dietary n-3 FA content can have a pronounced effect upon PGE2 levels and possesses the potential for influencing other immunomodulators.
C D Henderson; H S Black; J E Wolf
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  24     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-28     Completed Date:  1989-09-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  502-5     Citation Subset:  IM    
Photobiology Laboratory, Veterans Administration Medical Center, Houston, Texas.
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MeSH Terms
Corn Oil / pharmacology
Dietary Fats / pharmacology*
Dinoprostone / biosynthesis*,  blood
Dose-Response Relationship, Drug
Fatty Acids, Unsaturated / pharmacology*
Fish Oils / pharmacology
Mice, Hairless / radiation effects
Neoplasms, Radiation-Induced / prevention & control
Skin / metabolism
Ultraviolet Rays
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 363-24-6/Dinoprostone; 8001-30-7/Corn Oil; 8002-50-4/Menhaden oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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