Document Detail

Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC.
MedLine Citation:
PMID:  18423768     Owner:  NLM     Status:  MEDLINE    
The aims of this study were to investigate the effect of the oil content on the physicochemical properties of NLC and to elucidate the potential of NLC for skin targeting. The obtained results showed that an increase in the oil content did not affect the mean particle size of NLC but impacted on the zeta potential. The inner structure of NLC was influenced by the increasing proportion of oil towards the less ordered structure as confirmed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD), particularly for the higher medium chain triglycerides (MCT) loading. The data from proton nuclear magnetic resonance (1H NMR) revealed that cetyl palmitate nanoparticles did not completely recrystallize after cooling down to room temperature. 1H NMR and DSC results indicate that MCT molecules were restricted in the NLC as compared to the nanoemulsions (NE). Nile red distribution and penetration into skin from NLC were pronounced as compared to NE and dependent on the MCT loading. The deep penetration and high amount of Nile red were related to the occlusion factor. Moreover, the epidermal targeting was achieved by NLC applications, particularly those containing 5% MCT (NLC-5) depending on the amount of MCT loading.
Veerawat Teeranachaideekul; Prapaporn Boonme; Eliana Barbosa Souto; Rainer Helmut Müller; Varaporn Buraphacheep Junyaprasert
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-04
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  128     ISSN:  1873-4995     ISO Abbreviation:  J Control Release     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-20     Completed Date:  2008-09-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  134-41     Citation Subset:  IM    
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Thailand; Department of Pharmaceutics, Biopharmaceutics & Quality Management, Free University of Berlin, Germany.
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MeSH Terms
Administration, Cutaneous
Calorimetry, Differential Scanning
Drug Delivery Systems / methods
Emulsions / chemical synthesis,  chemistry
Fluorescent Dyes / administration & dosage,  chemistry,  pharmacokinetics
Magnetic Resonance Spectroscopy
Microscopy, Confocal
Middle Aged
Nanoparticles / chemistry*
Oxazines / administration & dosage,  chemistry,  pharmacokinetics*
Palmitates / chemistry
Particle Size
Skin / metabolism*
Skin Absorption
Static Electricity
Surface Properties
Transition Temperature
Triglycerides / chemistry*
X-Ray Diffraction
Reg. No./Substance:
0/Emulsions; 0/Fluorescent Dyes; 0/Oxazines; 0/Palmitates; 0/Triglycerides; 540-10-3/cetyl palmitate; 7385-67-3/nile red

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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