Document Detail

Influence of ocular tropicamide on exercise testing.
MedLine Citation:
PMID:  1286476     Owner:  NLM     Status:  MEDLINE    
This study was aimed to evaluate the effects of tropicamide 0.5% eye drops on cardiovascular parameters during exercise testing. The study group included 154 healthy subjects (mean age: 44.7 +/- 8 years). The subjects were divided into three groups according to the size of the pupils at the onset of exercise: A: pupils not dilated (n = 27), B: pupils partially dilated (n = 90) and C: pupils widely dilated (n = 37). They were compared to 66 healthy controls (age 43.8 +/- 8) who did not receive the drops. Rest and exercise parameters were affected in groups A and B, while the results of group C resembled those of the controls: (a) resting heart rate -66.7, 66.6, 70.9 and 69.3, respectively (p = 0.03); (b) heart rate at 50 and 100 W - 104, 107, 110 and 111 (p = 0.01) and 131, 131, 137, 139, respectively (p = 0.01); and (c) peak systolic blood pressure - 192, 186, 183, 175; respectively (p = 0.004). Reanalyzing the data by scoring of visual impairment gave identical results. As a whole, the study group achieved higher work loads than the controls (126 vs. 119 W; p = 0.03). We conclude that the instillation of ocular tropicamide has definite effects on cardiovascular parameters, both at rest and during exercise. Mainly, patients showed a lower heart rate at the initial levels of exercise. However, at symptom-limited level, tropicamide does not influence a patient's ability to achieve the target heart rate, and stress testing results are not altered by the drug.
A Pines; E Z Fisman; Y Drory; M Averbuch; E Ben-Ari; I Gelernter; Y Levo; J J Kellermann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  81     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1992  
Date Detail:
Created Date:  1993-03-15     Completed Date:  1993-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  172-7     Citation Subset:  IM    
Department of Medicine T, Ichilov Hospital, Tel-Aviv, Israel.
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MeSH Terms
Blood Pressure / drug effects
Electrocardiography / drug effects
Exercise Test / drug effects*
Heart Rate / drug effects
Middle Aged
Ophthalmic Solutions
Prospective Studies
Reflex, Pupillary / drug effects
Tropicamide / pharmacology*
Visual Acuity / drug effects
Reg. No./Substance:
0/Ophthalmic Solutions; 1508-75-4/Tropicamide

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