Document Detail

Influence of ocular hypotensive eyedrops on intraocular pressure fluctuation with postural change in eyes with normal-tension glaucoma.
MedLine Citation:
PMID:  17386282     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the effect of various ocular hypotensive eyedrops on the intraocular pressure (IOP) fluctuations caused by the postural change in patients with normal-tension glaucoma (NTG). DESIGN: Randomized crossover single-blind study. METHODS: Twenty-four eyes of 24 newly diagnosed NTG patients were enrolled. One of the three eyedrops including timolol maleate, latanoprost, and brinzolamide was randomly administered for one month. Each patient received all three eyedrops with a one-month washout period between the drugs. The IOP at baseline and after each treatment trial was measured in both sitting and supine positions. RESULTS: Compared with the baseline level, the magnitude of IOP elevation associated with the postural change did not alter significantly by the application of any eyedrops (one-way repeated-measures analysis of variance, P = .288). CONCLUSIONS: The mechanism of action underlying the IOP change with the postural change is different from the pharmacologic action of these hypotensive agents.
Takahiro Kiuchi; Yuta Motoyama; Tetsuro Oshika
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-12-20
Journal Detail:
Title:  American journal of ophthalmology     Volume:  143     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-27     Completed Date:  2007-04-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  693-5     Citation Subset:  AIM; IM    
Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan. <>
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MeSH Terms
Antihypertensive Agents / administration & dosage*
Cross-Over Studies
Glaucoma, Open-Angle / drug therapy*
Intraocular Pressure / drug effects*
Middle Aged
Ophthalmic Solutions / administration & dosage
Prospective Studies
Prostaglandins F, Synthetic / administration & dosage
Single-Blind Method
Sulfonamides / administration & dosage
Thiazines / administration & dosage
Timolol / administration & dosage
Tonometry, Ocular
Reg. No./Substance:
0/Antihypertensive Agents; 0/Ophthalmic Solutions; 0/Prostaglandins F, Synthetic; 0/Sulfonamides; 0/Thiazines; 130209-82-4/latanoprost; 138890-62-7/brinzolamide; 26839-75-8/Timolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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