| Influence of normothermic cardiopulmonary bypass on body oxygen metabolism during lung transplantation. | |
| | |
MedLine Citation:
|
PMID: 18204319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Studies have demonstrated that cardiopulmonary bypass (CPB) adversely affects pulmonary circulation, which is involved in metabolism in the lung, and that pulmonary circulation after CPB can restore the prostaglandin E2 (PGE2) level mainly standing for levels of key vasostimulators augmented during CPB, which may influence systemic tissue perfusion and body oxygen metabolism. However, in lung transplantation (Lx), pulmonary circulation is restored to the graft, which might induce another CPB reaction. We prospectively examined the influence of CPB on body oxygen metabolism in Lx. Left Lx was successfully performed on 10 dogs (group-on: with normothermic CPB without cardiac arrest, group-off: without CPB; n = 5 vs. 5). At 30 minutes after graft perfusion, the right pulmonary artery and bronchus were clamped. Body weight, donor-to-recipient body weight ratio, and clinical parameters were comparable between the two groups, except for the hematocrit level during CPB. At 90 minutes after graft perfusion, mixed venous oxygen saturation (SvO2) was lower (p < 0.01) and O2 extraction rate (p < 0.01), PGE2 (p = 0.025), and arterial blood ketone body ratio (KBR) (p < 0.01) were higher in group-on than in group-off, whereas these parameters were comparable before graft perfusion between the two groups. O2 consumption and acetic acid were higher in group-on than in group-off, whereas O2 delivery and 3-hydroxy propioic acid were comparable between the groups. In conclusion, Lx during CPB may induce a new inflammatory reaction and influence body oxygen metabolism, contrary to the restoration of pulmonary circulation after CPB. |
| | |
Authors:
|
Koichi Sato; Masanori Tsuchida; Masayuki Saito; Terumoto Koike; Jun-Ichi Hayashi |
Related Documents
:
|
12365519 - Effect of l-name on pulmonary arterial pressure, plasma nitric oxide and pulmonary hype... 17091009 - Suctioning prevents emboli during insertion of acetabular components without holes. 21549359 - Insights in starch acetylation in sub- and supercritical co(2). 15481699 - Cardiovascular and respiratory status in mechanically ventilated asphyxiated term infan... 1794919 - Total ligation of the left renal vein in the dog: an inappropriate model for varicocele. 7864479 - Treatment of verapamil overdose with glucagon in dogs. 1854569 - Aging, autonomic function, and the perception of angina. 2409389 - Reflex cardiovascular regulation in humans. 7239769 - Epidemiology of obesity and hypertension. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 54 ISSN: 1538-943X ISO Abbreviation: ASAIO J. Publication Date: 2008 Jan-Feb |
Date Detail:
|
Created Date: 2008-01-21 Completed Date: 2008-06-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
|
Languages: eng Pagination: 73-7 Citation Subset: IM |
Affiliation:
|
Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight Bronchi Cardiopulmonary Bypass / adverse effects* Dinoprostone / biosynthesis Hypothermia, Induced Inflammation Ketones / metabolism Lung Transplantation / methods* Models, Biological Oxygen / metabolism* Oxygen Consumption Pulmonary Artery / pathology Pulmonary Circulation Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Ketones; 363-24-6/Dinoprostone; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Platelet activation due to hemodynamic shear stresses: damage accumulation model and comparison to i...
Next Document: Systemic leukofiltration does not attenuate pulmonary injury after cardiopulmonary bypass.