Document Detail

Influence of noradrenaline on the respiratory status of Rana balcanica red cell suspension under normoxia, hypoxia and hypercapnia: alpha 1-receptor involvement.
MedLine Citation:
PMID:  10472127     Owner:  NLM     Status:  MEDLINE    
The effect of normoxia, hypoxia and hypercapnia on the extracellular pH, partial pressure carbon dioxide (pCO2), partial pressure oxygen (pO2) and HCO3- levels after noradrenaline treatment of Rana balcanica erythrocytes, was investigated. Noradrenaline caused a significant reduction of the extracellular pH which may have been due to the activation of red blood cell Na+/H+ exchange. Significant falls in the partial extracellular pressure of CO2 and O2 were evident. The initial reduction in extracellular pCO2 and pO2 was followed by a rise reflecting the desensitization of the Na+/H+ exchange after 15 min of hormone stimulation. Both hypercapnia and hypoxia increased the magnitude of these changes in relation to normoxia, although the greatest changes were observed under hypercapnic conditions. The involvement of alpha 1 receptors in regulating the concentration of respiratory gases after catecholamine stimulation was demonstrated. It is suggested that these responses increased the effectiveness of gas transfer over the respiratory surfaces.
M Kaloyianni; N Giagtzoglou; D Economidis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytobios     Volume:  98     ISSN:  0011-4529     ISO Abbreviation:  Cytobios     Publication Date:  1999  
Date Detail:
Created Date:  1999-09-28     Completed Date:  1999-09-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207227     Medline TA:  Cytobios     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  77-94     Citation Subset:  IM    
Zoology Department, School of Biology, Aristotle University of Thessaloniki, Greece.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology
Bicarbonates / blood
Blood Physiological Phenomena / drug effects*
Carbon Dioxide / blood
Erythrocytes / drug effects
Hydrogen-Ion Concentration
Norepinephrine / pharmacology*
Oxygen / blood
Prazosin / pharmacology*
Ranidae / physiology*
Receptors, Adrenergic, alpha-1 / antagonists & inhibitors,  metabolism*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Bicarbonates; 0/Receptors, Adrenergic, alpha-1; 124-38-9/Carbon Dioxide; 19216-56-9/Prazosin; 51-41-2/Norepinephrine; 7782-44-7/Oxygen

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