Document Detail

Influence of nonhemodynamic factors on the microcirculation in moderate arterial essential hypertension.
MedLine Citation:
PMID:  1789951     Owner:  NLM     Status:  MEDLINE    
This study is aimed at examining the role of non-hemodynamic factors on the impaired microcirculation in patients with moderate essential hypertension. In a series of 31 patients (mean age, 47.8 +/- 1.1 years) with newly diagnosed untreated moderate essential hypertension (mean systolic blood pressure 161.7 +/- 2.0 mm Hg, mean diastolic blood pressure 102.4 +/- 1.5 mm Hg), parameters of the capillaroscopic examination of the finger microcirculation (mean number of capillaries, NRCAP), length of the capillaries (LECAP, microns), diameter micron) of the efferent (EFDI) and afferent (AFDI) apillaries, and mean red blood cell velocity (RBCV, microns/sec), which was measured by the flying spot technique, were correlated with a number of hormones (sampled after an overnight fast) including: plasma renin activity, aldosterone, and parathyroid hormone (PTH). A significant correlation (P less than .05) could be obtained between several parameters of the microcirculation and PTH:PTH (23.8 +/- 1.4 pg/mL)-NRCAP (14.9 +/- 0.5): r = -0.440, P = .013; PTH-AFDI (4.0 +/- 0.5 microns): r = 0.442, P = .012; PTH-EFDI (2.8 +/- 0.5 microns): r = 0.416, P = .019; PTH-RBCV (711 +/- 69 microns/sec): r = -0.351, P = .05. Furthermore, 24-h urinary norepinephrine (U-NOR) and afferent and efferent diameter of the capillaries intercorrelated significantly: U-NOR (46.0 +/- 6.2 micrograms/24 h)-AFDI: r = 0.439, P = .034; U-NOR-EFDI; r = 0.462, P = .025. This study shows that in patients with moderate essential arterial hypertension nonhemodynamic factors have an influence at the level of the microcirculation.
D Duprez; M De Buyzere; T De Backer; J Vercammen; J M Kaufman; M Van Hoecke; A Vermeulen; D Clement
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  4     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-03-31     Completed Date:  1992-03-31     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  885-9     Citation Subset:  IM    
Department of Cardiology-Angiology, University Hospital, Gent, Belgium.
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MeSH Terms
Aldosterone / blood
Blood Pressure / physiology
Hemodynamics / physiology
Hypertension / physiopathology*
Microcirculation / drug effects*,  physiology
Middle Aged
Norepinephrine / urine
Parathyroid Hormone / blood,  physiology*
Renin / blood
Reg. No./Substance:
0/Parathyroid Hormone; 51-41-2/Norepinephrine; 52-39-1/Aldosterone; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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