| Influence of nonhemodynamic factors on the microcirculation in moderate arterial essential hypertension. | |
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MedLine Citation:
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PMID: 1789951 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study is aimed at examining the role of non-hemodynamic factors on the impaired microcirculation in patients with moderate essential hypertension. In a series of 31 patients (mean age, 47.8 +/- 1.1 years) with newly diagnosed untreated moderate essential hypertension (mean systolic blood pressure 161.7 +/- 2.0 mm Hg, mean diastolic blood pressure 102.4 +/- 1.5 mm Hg), parameters of the capillaroscopic examination of the finger microcirculation (mean number of capillaries, NRCAP), length of the capillaries (LECAP, microns), diameter micron) of the efferent (EFDI) and afferent (AFDI) apillaries, and mean red blood cell velocity (RBCV, microns/sec), which was measured by the flying spot technique, were correlated with a number of hormones (sampled after an overnight fast) including: plasma renin activity, aldosterone, and parathyroid hormone (PTH). A significant correlation (P less than .05) could be obtained between several parameters of the microcirculation and PTH:PTH (23.8 +/- 1.4 pg/mL)-NRCAP (14.9 +/- 0.5): r = -0.440, P = .013; PTH-AFDI (4.0 +/- 0.5 microns): r = 0.442, P = .012; PTH-EFDI (2.8 +/- 0.5 microns): r = 0.416, P = .019; PTH-RBCV (711 +/- 69 microns/sec): r = -0.351, P = .05. Furthermore, 24-h urinary norepinephrine (U-NOR) and afferent and efferent diameter of the capillaries intercorrelated significantly: U-NOR (46.0 +/- 6.2 micrograms/24 h)-AFDI: r = 0.439, P = .034; U-NOR-EFDI; r = 0.462, P = .025. This study shows that in patients with moderate essential arterial hypertension nonhemodynamic factors have an influence at the level of the microcirculation. |
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Authors:
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D Duprez; M De Buyzere; T De Backer; J Vercammen; J M Kaufman; M Van Hoecke; A Vermeulen; D Clement |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hypertension Volume: 4 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-03-31 Completed Date: 1992-03-31 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 885-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology-Angiology, University Hospital, Gent, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood Blood Pressure / physiology Hemodynamics / physiology Humans Hypertension / physiopathology* Microcirculation / drug effects*, physiology Middle Aged Norepinephrine / urine Parathyroid Hormone / blood, physiology* Renin / blood |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 51-41-2/Norepinephrine; 52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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