| Influence of non-gonadotrophic hormones on gonadal function. | |
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MedLine Citation:
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PMID: 10773389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhibins and activins are dimeric glycoproteins, member of the transforming growth factor beta (TGF beta) superfamily. The main source and targets of inhibins during the fertile age, in non pregnant women, are the ovaries, while during pregnancy placental production becomes predominant. Activin is produced from several organs: brain, ovary, uterus, placenta and spleen. During the menstrual cycles, inhibin B concentrations rise in the follicular phase with a peak after the ovulation peak of LH, inhibin A becomes predominant in the luteal phase. During reproductive life no significant change of activin A serum concentrations have been demonstrated. Inhibins and activins play an important biological role in the regulation of the HPO axis. The evaluation of inhibins and activins change is useful in understanding the pathophysiology of gynecological diseases and in the diagnosis of obstetric and gynecological pathologies. |
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Authors:
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I Pezzani; F M Reis; C Di Leonardo; S Luisi; M Santuz; L Driul; L Cobellis; F Petraglia |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Molecular and cellular endocrinology Volume: 161 ISSN: 0303-7207 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-07-13 Completed Date: 2000-07-13 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 37-42 Citation Subset: IM |
Affiliation:
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Department of Surgical Sciences, Chair of Obstetrics and Gynecology, University of Udine, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activins Animals Female Follicle Stimulating Hormone / antagonists & inhibitors Genital Neoplasms, Female / metabolism Growth Substances / blood, pharmacology, physiology Humans Infertility, Female / metabolism, physiopathology Inhibins / blood, pharmacology, physiology* Ovary / drug effects*, physiology Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Growth Substances; 104625-48-1/Activins; 57285-09-3/Inhibins; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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