| Influence of non-Newtonian properties of blood on the wall shear stress in human atherosclerotic right coronary arteries. | |
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MedLine Citation:
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PMID: 21379375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this work is to investigate the effect of non-Newtonian properties of blood on the wall shear stress (WSS) in atherosclerotic coronary arteries using both Newtonian and non-Newtonian models. Numerical simulations were performed to examine how the spatial and temporal WSS distributions are influenced by the stenosis size, blood viscosity, and flow rate. The computational results demonstrated that blood viscosity properties had considerable effect on the magnitude of the WSS, especially where disturbed flow was observed. The WSS distribution is highly non-uniform both temporally and spatially, especially in the stenotic region. The maximum WSS occurred at the proximal side of the stenosis, near the outer wall in the curved artery with no stenosis. The lumen area near the inner wall distal to the stenosis region experienced a lower WSS during the entire cardiac cycle. Among the factors of stenosis size, blood viscosity, and flow rate, the size of the stenosis has the most significant effect on the spatial and temporal WSS distributions qualitatively and quantitatively. |
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Authors:
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Biyue Liu; Dalin Tang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Molecular & cellular biomechanics : MCB Volume: 8 ISSN: 1556-5297 ISO Abbreviation: Mol Cell Biomech Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-10 Completed Date: 2011-07-18 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 101253756 Medline TA: Mol Cell Biomech Country: United States |
Other Details:
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Languages: eng Pagination: 73-90 Citation Subset: IM |
Affiliation:
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Department of Mathematics, Monmouth University, West Long Branch, NJ 07764, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atherosclerosis
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complications,
physiopathology,
radiography Coronary Angiography Coronary Stenosis / complications, pathology, physiopathology*, radiography Coronary Vessels / pathology, physiopathology* Hemorheology / physiology* Humans Models, Cardiovascular Stress, Mechanical* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 EB004759/EB/NIBIB NIH HHS; R01 EB004759-05/EB/NIBIB NIH HHS; R01 EB004759-06/EB/NIBIB NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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