| Influence of nitrous oxide on minimum alveolar concentration of sevoflurane for laryngeal mask insertion in children. | |
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MedLine Citation:
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PMID: 14576538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inhalational induction with sevoflurane and nitrous oxide is frequently used for Laryngeal Mask Airway (LMA; Laryngeal Mask Company, Henley-on-Thames, United Kingdom) insertion in children. The authors determined the influence of nitrous oxide on the minimum alveolar concentration (MAC) of sevoflurane for LMA insertion. METHODS: One hundred twenty unpremedicated children (age, 1-9 yr; American Society of Anesthesiologists physical status I) were randomly assigned to receive 1 of 15 end-tidal concentrations of nitrous oxide and sevoflurane for inhalational induction via a facemask: 0% nitrous oxide with 1.2, 1.4, 1.6, 1.8, or 2.0% sevoflurane; 33% nitrous oxide with 0.8, 1.0, 1.2, 1.4, or 1.6% sevoflurane; or 67% nitrous oxide with 0.4, 0.6, 0.8, 1.0, or 1.2% sevoflurane. The LMA was inserted after steady state end-tidal anesthetic concentrations had been maintained for 15 min. The response to insertion was recorded by three independent blinded observers. The interaction between nitrous oxide and sevoflurane was determined using logistic regression analysis. RESULTS: The MAC of sevoflurane for LMA insertion (95% confidence limit) was 1.57% (1.42-1.72%), and the concentration of sevoflurane required to prevent movement in 95% of children was 1.99% (1.81-2.57%). The addition of 33% and 67% nitrous oxide linearly decreased the MAC of sevoflurane for LMA insertion by 22% and 49%, respectively (P < 0.001). The interaction coefficient between nitrous oxide and sevoflurane did not differ from zero (P = 0.7843), indicating that the relation was additive. CONCLUSIONS: Nitrous oxide and sevoflurane suppress the responses to LMA insertion in a linear and additive fashion in children. |
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Authors:
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Shinichi Kihara; Yuichi Yaguchi; Shinichi Inomata; Seiji Watanabe; Joseph R Brimacombe; Noriko Taguchi; Tetsuya Komatsuzaki |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anesthesiology Volume: 99 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-24 Completed Date: 2003-11-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 1055-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesia, Mito Saiseikai General Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Anesthetics, Inhalation* / administration & dosage, pharmacokinetics Child Child, Preschool Dose-Response Relationship, Drug Female Humans Infant Laryngeal Masks* Logistic Models Male Methyl Ethers* / administration & dosage Monitoring, Intraoperative Movement / drug effects Nitrous Oxide* / administration & dosage, pharmacokinetics Pulmonary Alveoli / metabolism* Single-Blind Method |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 28523-86-6/sevoflurane |
| Comments/Corrections | |
Comment In:
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Anesthesiology. 2004 Sep;101(3):801; author reply 801
[PMID:
15329613
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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