Document Detail

Influence of nifedipine coat-core and amlodipine on systemic arterial stiffness modulated by sympathetic and parasympathetic activity in hypertensive patients.
MedLine Citation:
PMID:  19373239     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to compare the effects of nifedipine coat-core (once daily formulation) and amlodipine on systemic arterial stiffness in patients with hypertension. Study drugs were assigned by the randomized open-label crossover method. After the blood pressure was maintained below 130/85 mm Hg for 8 months by treatment with either drug in 48 hypertensive patients (aged 63.2+/-6.9 years; 64.5% men), they were switched to the other drug for another 8 months. The blood pressure, heart rate, plasma catecholamine level and brachial-ankle pulse wave velocity were measured before and after a bicycle ergometer testing. Heart rate recovery was calculated from the change of the heart rate after treadmill exercise testing. The high-frequency and low-frequency components of the heart rate variability spectrum were analyzed from 24-h Holter electrocardiograms. The change of blood pressure after exercise testing showed no significant difference between the two medications. However, the increases of heart rate, noradrenalin and branchial-ankle pulse wave velocity after exercise were significantly smaller with nifedipine treatment than with amlodipine (P=0.0472, P=0.006 and P=0.0472, respectively). Heart rate recovery was significantly faster with nifedipine treatment (P=0.0280). The nighttime high-frequency component of heart rate variability was significantly larger after nifedipine treatment than after amlodipine (P=0.0259), while the nighttime low/high-frequency ratio was significantly smaller with nifedipine (P=0.0429). Nifedipine reduced functional arterial stiffness and improved heart rate recovery by altering the autonomic activity balance in hypertensive patients.
Michinari Fukuda; Takashi Masuda; Misao N Ogura; Tatsumi Moriya; Keiji Tanaka; Kazuya Yamamoto; Akira Ishii; Ryusuke Yonezawa; Chiharu Noda; Tohru Izumi
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2009-04-17
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  32     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-06     Completed Date:  2009-11-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  392-8     Citation Subset:  IM    
Department of Rehabilitation, Kitasato University School of Allied Health Sciences, Kanagawa, Japan.
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MeSH Terms
Amlodipine / administration & dosage*
Arteries / drug effects*,  innervation,  physiopathology
Blood Pressure / drug effects*
Calcium Channel Blockers / administration & dosage*
Heart / drug effects,  physiopathology
Heart Rate / drug effects
Hypertension / drug therapy*,  physiopathology
Middle Aged
Nifedipine / administration & dosage*
Parasympathetic Nervous System / physiopathology*
Sympathetic Nervous System / physiopathology*
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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