| Influence of a new monomeric nonionic radiographic contrast medium (iobitridol-350 versus NaCl) on cutaneous microcirculation: single-center, prospective, randomized, double-blind phase IV study in parallel group design. | |
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MedLine Citation:
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PMID: 11078635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This single-center, prospective, randomized, double-blind phase IV study with parallel-group design was performed to test whether injection of a newly designed non-ionic monomeric radiographic contrast medium in the axillary artery influences the ipsilateral cutaneous microcirculation. Twenty patients with coronary heart disease or suspected coronary heart disease were investigated. Ten patients received iobitridol and 10 normal saline solution. The confirmatory target variable was the capillary erythrocyte velocity (v(RBC)). The v(RBC) was continuously recorded before and up to 3 min after the injection of iobitridol or normal saline solution and subsequently evaluated off-line. Thirty seconds after injection of 20 ml iobitridol, v(RBC) was reduced by 32% (P < 0.05). This was the strongest reduction, but v(RBC) was reduced at all time points measured up to 180 s following the injection (P < 0.05 up to 180 s). The overall reduction in v(RBC) was also statistically significant (P 0.0446). In contrast, there was a tendency toward an increase in v(RBC) following injection of 20 ml normal saline (P 0.0512). There was also a tendency toward a difference in the time course of changes in v(RBC) following injection of iobitridol compared to normal saline (P 0.0607). The decrease in v(RBC) following iobitridol injection (standardized difference (SD) according to Cohen, 0.67) can be regarded as biometrically weak, and the increase following normal saline injection (SD, 0.24) as very weak. The microcirculatory disturbance induced by iobitridol injection is less severe than that due to comparable high-viscosity contrast media. |
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Authors:
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R Bach; U Gerk; C Mrowietz; F Jung |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase IV; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Microvascular research Volume: 60 ISSN: 0026-2862 ISO Abbreviation: Microvasc. Res. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-02-02 Completed Date: 2001-02-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0165035 Medline TA: Microvasc Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 193-200 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Academic Press. |
Affiliation:
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Dresdner Institut für Herz- und Kreislaufforschung, Forststrasse 5, Dresden, 01099, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Flow Velocity / drug effects Blood Viscosity / drug effects Contrast Media / administration & dosage, adverse effects* Coronary Disease / physiopathology, radiography Double-Blind Method Female Heart Catheterization / adverse effects Humans Injections, Intra-Arterial Iohexol / administration & dosage, adverse effects, analogs & derivatives* Male Microcirculation / drug effects Middle Aged Prospective Studies Skin / blood supply*, drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/iobitridol; 66108-95-0/Iohexol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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