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Influence of new late effects on quality of life over time in Hodgkin lymphoma Survivors: a longitudinal survey study.
MedLine Citation:
PMID:  22875834     Owner:  NLM     Status:  Publisher    
BackgroundLong-term Hodgkin lymphoma (HL) survivors are known to have diminished quality of life (QoL). However, limited data are available on temporal changes in QoL and factors associated with the changes.MethodsIn 2010, we conducted a follow-up questionnaire study on 273 HL survivors who participated in a 2003 questionnaire study on late effects after HL. The questionnaire items were limited to new late complications and reassessment of QoL and fatigue level, using the Short Form 36 (SF-36) and the Functional Assessment of Chronic Illness Therapy-Fatigue instruments, respectively. We compared the results from the 2003 and the 2010 questionnaires, and QoL score changes between survivors with and without new late complications during the 7-year period.ResultsThere was a significant decline in the SF-36 Physical Component Summary score (median change, -1.8; P < 0.0001) over the time period. The decline was significantly greater among survivors with a new cardiac (P = 0.005) or pulmonary (P < 0.0001) complication, compared with those without any new complications. The survivors reporting new cardiac complications also experienced significantly greater worsening of fatigue scores (P = 0.004).ConclusionThe significant association between the development of new cardiopulmonary complications and decline in QoL and energy level of HL survivors provides further support for current efforts to reduce treatment to limit late effects.
N Khimani; Y-H Chen; P M Mauch; C Recklitis; L Diller; B Silver; A K Ng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-8
Journal Detail:
Title:  Annals of oncology : official journal of the European Society for Medical Oncology / ESMO     Volume:  -     ISSN:  1569-8041     ISO Abbreviation:  Ann. Oncol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007735     Medline TA:  Ann Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston.
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