| Influence of new gamma-hydroxybutyric acid amide analogues on the central nervous system activity in mice. | |
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MedLine Citation:
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PMID: 12866734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study investigates the activity of four gamma-hydroxybutyric acid amide analogues (BM-68, BM-74, BM-75 and BM-76) in two models of chemically induced seizures, i.e. picrotoxin- and pentetrazole-induced seizures and in the thiopental-induced sleep test. The results of pharmacological in vivo experiments with the gamma-hydroxybutyric acid amide analogues presented below show that the compounds possess variable influence on the central nervous system in mice. |
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Authors:
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Kinga Sałat; Anna Mendyk; Tadeusz Librowski; Ryszard Czarnecki; Barbara Malawska |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Polish journal of pharmacology Volume: 54 ISSN: 1230-6002 ISO Abbreviation: Pol J Pharmacol Publication Date: 2002 Nov-Dec |
Date Detail:
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Created Date: 2003-07-17 Completed Date: 2003-08-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9313882 Medline TA: Pol J Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 731-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacodynamics, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Kraków, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Central Nervous System / drug effects*, physiology Hydroxybutyrates / chemical synthesis*, pharmacology*, therapeutic use Male Mice Seizures / chemically induced, prevention & control Sleep / drug effects, physiology gamma-Aminobutyric Acid / analogs & derivatives*, pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Hydroxybutyrates; 56-12-2/gamma-Aminobutyric Acid; 591-81-1/4-hydroxybutyric acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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